Removal of the superficial zone of bovine articular cartilage does not increase its frictional coefficient  R. Krishnan, M. Caligaris, R.L. Mauck, C.T.

Slides:



Advertisements
Similar presentations
Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.
Advertisements

B. Bai, Y. Li  Osteoarthritis and Cartilage 
C.P. Neu, T. Novak, K.F. Gilliland, P. Marshall, S. Calve 
The contribution of collagen fibers to the mechanical compressive properties of the temporomandibular joint disc  S. Fazaeli, S. Ghazanfari, V. Everts,
The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-β3  E.G. Lima, M.Phil., M.S., L. Bian,
Yevgeniya Kobrina, Lassi Rieppo, Simo Saarakkala, Jukka S
Chondroitin sulphate: an effective joint lubricant?
Diffusion of Gd-DTPA2− into articular cartilage
T.A. Schmidt, Ph.D., R.L. Sah, M.D., Sc.D. 
Hisham A. Alhadlaq, M.S., Yang Xia, Ph.D.  Osteoarthritis and Cartilage 
The epidemiology and impact of pain in osteoarthritis
Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage  Peggy M.
Cell deformation behavior in mechanically loaded rabbit articular cartilage 4 weeks after anterior cruciate ligament transection  S.M. Turunen, S.-K.
Effect of nominal stress on the long term friction, deformation and wear of native and glycosaminoglycan deficient articular cartilage  J. Katta, Z. Jin,
A.J. McGregor, B.G. Amsden, S.D. Waldman  Osteoarthritis and Cartilage 
H.T. Kokkonen, J.S. Jurvelin, V. Tiitu, J. Töyräs 
Investigation of the frictional response of osteoarthritic human tibiofemoral joints and the potential beneficial tribological effect of healthy synovial.
M.L. Hall, D.A. Krawczak, N.K. Simha, J.L. Lewis 
A.R. Gannon, T. Nagel, D.J. Kelly  Osteoarthritis and Cartilage 
S.M.T. Chan, C.P. Neu, G. DuRaine, K. Komvopoulos, A.H. Reddi 
The layered structure of the articular surface
Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives  Y. Henrotin  Osteoarthritis and Cartilage 
R. Mhanna, E. Öztürk, P. Schlink, M. Zenobi-Wong 
A. Williams, Y. Qian, C.R. Chu  Osteoarthritis and Cartilage 
B. Kaleem, F. Maier, H. Drissi, D.M. Pierce 
Mechanical response of articular cartilage damaged by macro cracks
Reinforcement of articular cartilage with a tissue-interpenetrating polymer network reduces friction and modulates interstitial fluid load support  B.G.
Structural characteristics of the collagen network in human normal, degraded and repair articular cartilages observed in polarized light and scanning.
L. McCann, E. Ingham, Z. Jin, J. Fisher  Osteoarthritis and Cartilage 
The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading  R.L. Mauck, C.C-B. Wang, E.S.
Time to be positive about negative data?
L. Bian, S. L. Angione, K. W. Ng, E. G. Lima, D. Y. Williams, D. Q
Articular cartilage MR imaging and thickness mapping of a loaded knee joint before and after meniscectomy  Y. Song, M.S., J.M. Greve, M.S., D.R. Carter,
Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging  S.K. de Visser, B.Eng. (Med.), R.W. Crawford, D.Phil.,
J. Ranstam  Osteoarthritis and Cartilage 
Nonlinear optical microscopy of articular cartilage
The contribution of collagen fibers to the mechanical compressive properties of the temporomandibular joint disc  S. Fazaeli, S. Ghazanfari, V. Everts,
New insights into the role of the superficial tangential zone in influencing the microstructural response of articular cartilage to compression  S.L.
H. Sadeghi, D.E.T. Shepherd, D.M. Espino  Osteoarthritis and Cartilage 
J. Desrochers, M.W. Amrein, J.R. Matyas  Osteoarthritis and Cartilage 
V. Morel, Ph.D., A. Merçay, M.Sc., T.M. Quinn, Ph.D. 
Opposing cartilages in the patellofemoral joint adapt differently to long-term cruciate deficiency: chondrocyte deformation and reorientation with compression 
The changing role of the superficial region in determining the dynamic compressive properties of articular cartilage during postnatal development  A.R.
Effects of sustained interstitial fluid pressurization under migrating contact area, and boundary lubrication by synovial fluid, on cartilage friction 
Regionally distinct f-actin networks within articular cartilage
Degeneration of patellar cartilage in patients with recurrent patellar dislocation following conservative treatment: evaluation with delayed gadolinium-enhanced.
Collagen fibril stiffening in osteoarthritic cartilage of human beings revealed by atomic force microscopy  C.-Y. Wen, C.-B. Wu, B. Tang, T. Wang, C.-H.
A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading  H.E. Kloefkorn, B.Y. Jacobs,
Meniscectomy alters the dynamic deformational behavior and cumulative strain of tibial articular cartilage in knee joints subjected to cyclic loads  Y.
F.W. Roemer, M.D.  Osteoarthritis and Cartilage 
Who should have a joint replacement? A plea for more ‘phronesis’
In vitro glycation of articular cartilage alters the biomechanical response of chondrocytes in a depth-dependent manner  J.M. Fick, M.R.J. Huttu, M.J.
Shearing of synovial fluid activates latent TGF-β
Scaffold degradation elevates the collagen content and dynamic compressive modulus in engineered articular cartilage  K.W. Ng, Ph.D., L.E. Kugler, B.S.,
Templates of the cartilage layers of the patellofemoral joint and their use in the assessment of osteoarthritic cartilage damage  Z.A Cohen, Ph.D., V.C.
Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography  N.J. Willett, T. Thote, M. Hart,
E.M. Darling, Ph.D., S. Zauscher, Ph.D., F. Guilak, Ph.D. 
D.J. Hunter  Osteoarthritis and Cartilage 
B. Zielinska, M. Killian, M. Kadmiel, M. Nelsen, T.L. Haut Donahue 
Cellular origin of neocartilage formed at wound edges of articular cartilage in a tissue culture experiment  P.K. Bos, M.D., Ph.D., N. Kops, B.Sc., J.A.N.
C. Ratzlaff, M. Koehoorn, J. Cibere, J. Kopec 
A.R. Tan, E.Y. Dong, G.A. Ateshian, C.T. Hung 
Osteoarthritis year 2012 in review: biology
R. B. Souza, C. Stehling, B. T. Wyman, M. -P. Hellio Le Graverand, X
The elastic modulus of articular cartilage at nano-scale and micro-scale measured using indentation type atomic force microscopy  P. Rahnamay Moshtagh,
Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla  S. Apprich, G.H.
Effects of helium–neon laser on the mucopolysaccharide induction in experimental osteoarthritic cartilage  Y.-S. Lin, M.Sc, Dr M.-H. Huang, M.D., Ph.D.,
Osteoarthritis year in review 2016: mechanics
M. Doherty, P. Dieppe  Osteoarthritis and Cartilage 
General Information Osteoarthritis and Cartilage
Presentation transcript:

Removal of the superficial zone of bovine articular cartilage does not increase its frictional coefficient  R. Krishnan, M. Caligaris, R.L. Mauck, C.T. Hung, K.D. Costa, G.A. Ateshian  Osteoarthritis and Cartilage  Volume 12, Issue 12, Pages 947-955 (December 2004) DOI: 10.1016/j.joca.2004.08.009 Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Schematic of friction device. Osteoarthritis and Cartilage 2004 12, 947-955DOI: (10.1016/j.joca.2004.08.009) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Average curves showing variation of the effective friction coefficient (μeff) as a function of time for (a) test 1 and test 2 in control and treated groups from experiment 1; (b) test 1 and test 2 in control and treated groups from experiment 2; (c) friction tests on articular surface and corresponding side opposite the surface (microtomed deep zone) from experiment 3. Osteoarthritis and Cartilage 2004 12, 947-955DOI: (10.1016/j.joca.2004.08.009) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Summary of frictional results from surface removal tests. Microtomed specimens are in test 2 of the treated group. (a) μmin; (b) μeq; *P≤0.001. Osteoarthritis and Cartilage 2004 12, 947-955DOI: (10.1016/j.joca.2004.08.009) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Average compressive strain response (creep displacement/original thickness) over all specimens in experiment 2, for test 1 and test 2 of the treated group (before and after surface removal). The creep strain was 0.645±0.082 in test 1 and 0.653±0.157 in test 2, with no statistical difference observed (P=0.91). Osteoarthritis and Cartilage 2004 12, 947-955DOI: (10.1016/j.joca.2004.08.009) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Immunohistochemistry: Fluorescent images of representative samples from (a, b) group I and (c, d) group II, showed SZP present at the articular surface and within the superficial zone; (e, f) group III (microtomed surface) and (g, h) group III (microtomed deep zone) showed negligible SZP at the microtomed surface or the deep zone. (a, c, e, g) 20× magnification, scale bar=100μm; (b, d, f, h) 50× magnification, scale bar=50μm. Arrow indicates surface of interest in each image. Osteoarthritis and Cartilage 2004 12, 947-955DOI: (10.1016/j.joca.2004.08.009) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 6 Atomic force microscopy: (a, b) Intact articular surface from group 1; (c, d) microtomed surface zone from group 2; (e, f) microtomed deep zone from group 3. Z-direction scale bar=5μm. Osteoarthritis and Cartilage 2004 12, 947-955DOI: (10.1016/j.joca.2004.08.009) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions