Diffuse Alveolar Hemorrhage Temporally Related to Cocaine Smoking

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Diffuse Alveolar Hemorrhage Temporally Related to Cocaine Smoking Richard J. Murray, M.D., Robert J. Albin, M.D., Wolfgang Mergner, M.D., Gerard J. Criner, M.D. CHEST Volume 93, Issue 2, Pages 427-429 (February 1988) DOI: 10.1378/chest.93.2.427 Copyright © 1988 The American College of Chest Physicians Terms and Conditions

Figure 1 Admission PA chest radiograph. Bilateral alveolar infiltrates are present with predominantly lower lobe involvement. The cardiac silhouette is normal in size. CHEST 1988 93, 427-429DOI: (10.1378/chest.93.2.427) Copyright © 1988 The American College of Chest Physicians Terms and Conditions

Figure 2 Lung tissue with intraalveolar hemorrhage and marked proliferation of type 2 pneumocytes. Note the intraalveolar and interstitial macrophages. There is no evidence of vasculitis. (H and E, original magnification, 250X.) A = Intraalveolar; I = interstitial. Inset—Lung tissue in less involved area. Note the focal septal enlargement. (H and E, original magnification, 40X.) CHEST 1988 93, 427-429DOI: (10.1378/chest.93.2.427) Copyright © 1988 The American College of Chest Physicians Terms and Conditions

Figure 3 Electron photomicrograph of the alveolar septum. Note two type 2 pneumocytes and an intra-alveolar red blood cell. There is septal fibrosis. Two macrophages are noted in the septum containing pigment (Uranyl acetate and lead citrate, original magnification, 3000X.) col = collagen; pH = type 2 pneumocytes; mac = macrophage. CHEST 1988 93, 427-429DOI: (10.1378/chest.93.2.427) Copyright © 1988 The American College of Chest Physicians Terms and Conditions