AJKD Atlas of Renal Pathology: Alport Syndrome

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AJKD Atlas of Renal Pathology: Alport Syndrome Agnes B. Fogo, MD, Mark A. Lusco, MD, Behzad Najafian, MD, Charles E. Alpers, MD American Journal of Kidney Diseases Volume 68, Issue 4, Pages e15-e16 (October 2016) DOI: 10.1053/j.ajkd.2016.08.002 Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Alport syndrome with segmental and global glomerulosclerosis with proportional interstitial fibrosis (Jones silver stain). Reproduced with permission from AJKD 35(1):e1-e2. American Journal of Kidney Diseases 2016 68, e15-e16DOI: (10.1053/j.ajkd.2016.08.002) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Alport syndrome with interstitial foamy macrophages (periodic acid–Schiff stain). Reproduced with permission from AJKD 35(1):e1-e2. American Journal of Kidney Diseases 2016 68, e15-e16DOI: (10.1053/j.ajkd.2016.08.002) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Alport syndrome with discontinuous staining for alpha 5 subtype of collagen type IV along glomerular basement membranes, Bowman's capsule, and distal tubule basement membranes, consistent with a carrier state of X-linked Alport syndrome in a female patient (immunofluorescence microscopy; alpha 5 subtype of collagen type IV staining). American Journal of Kidney Diseases 2016 68, e15-e16DOI: (10.1053/j.ajkd.2016.08.002) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Alport syndrome with irregular thinning and thickening glomerular basement membranes with lamellated and basket-weave appearance (electron microscopy). Reproduced with permission from AJKD 35(1):e1-e2. American Journal of Kidney Diseases 2016 68, e15-e16DOI: (10.1053/j.ajkd.2016.08.002) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 5 Alport syndrome with basket-weave and lamellated appearance of the glomerular basement membrane (electron microscopy). American Journal of Kidney Diseases 2016 68, e15-e16DOI: (10.1053/j.ajkd.2016.08.002) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions