High-sensitivity C-reactive protein and long term reperfusion success of primary percutaneous intervention in ST-elevation myocardial infarction Hilde.

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High-sensitivity C-reactive protein and long term reperfusion success of primary percutaneous intervention in ST-elevation myocardial infarction Hilde E. Groot, Jacco C. Karper, Erik Lipsic, Dirk J. van Veldhuisen, Iwan C.C. van der Horst, Pim van der Harst International Journal of Cardiology Volume 248, Pages 51-56 (December 2017) DOI: 10.1016/j.ijcard.2017.08.027 Copyright © 2017 Terms and Conditions

Fig. 1 hs-CRP levels and NT-proBNP levels over time in 376 patients with impaired reperfusion and normal reperfusion. Mixed model analysis was used to compare hs-CRP and NT-proBNP levels within and between reperfusion groups. Data are presented as mean and standard error of the mean (SEM). NS=not significant. Fig. 1A depicts the proportion of patients with impaired reperfusion between the lowest (baseline 0–1mg/l, 2w 0–0.9mg/l, 7w 0–0.8mg/l, 4m 0–0.7mg/l) and highest quartile (baseline>4.3mg/l, 2w>5.0mg/l, 7w>3.3mg/l, 4m>2.5mg/l) of hs-CRP levels. Fig. 1B and C depict hs-CRP and NT-proBNP levels between the reperfusion groups on the same time points. Fig. 1D shows the decrease within reperfusion groups between consecutive time points. hs-CRP remained significantly higher in patients with impaired reperfusion for 7weeks (Fig. A). NT-proBNP levels were also higher in these patients (Fig. B). Fig. C depicts a combination of Figs. A and B in order to show the parallelism of the biomarkers in both reperfusion groups. Furthermore, hs-CRP levels decreased significantly in both reperfusion groups between 2 and 7weeks, whereas NT-pro BNP levels differed between all consecutive time points (Fig. C). International Journal of Cardiology 2017 248, 51-56DOI: (10.1016/j.ijcard.2017.08.027) Copyright © 2017 Terms and Conditions

Supplemental Fig. 1 The ratio between hs-CRP and NT-proBNP over time in 376 patients with impaired reperfusion and normal reperfusion. Mixed model analysis was used to compare between reperfusion groups. Data are presented as mean and standard error of the mean (SEM). NS=not significant. The ratio did not differ between reperfusion groups. International Journal of Cardiology 2017 248, 51-56DOI: (10.1016/j.ijcard.2017.08.027) Copyright © 2017 Terms and Conditions