Sevelamer Hydrochloride Binds Phosphate Released from Phytate in Chicks Fed 1α- Hydroxy Cholecalciferol Elizabeth A. Bobeck, BS, Katie M. Meyer, MS, Christian.

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Presentation transcript:

Sevelamer Hydrochloride Binds Phosphate Released from Phytate in Chicks Fed 1α- Hydroxy Cholecalciferol Elizabeth A. Bobeck, BS, Katie M. Meyer, MS, Christian Helvig, PhD, Martin Petkovich, PhD, Mark E. Cook, PhD Journal of Renal Nutrition Volume 23, Issue 1, Pages 21-27 (January 2013) DOI: 10.1053/j.jrn.2011.12.005 Copyright © 2013 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 (A). Experiment 1 plasma phosphate (mg/dL) treatment averages shown with standard error bars (n ≥ 16). Chicks were fed a basal diet with and without sevelamer or 1α-(OH) D3 for 10 days, starting on day 3 of age, and phosphate was determined from plasma. abMeans with different letter superscripts are different, P < .0001. Interaction of sevelamer and 1α-(OH) D3 was significant (P < .002). (B). Experiment 2 plasma phosphate (mg/dL) treatment average shown with standard error bars (n ≥ 10). Chicks were fed a basal diet with or without sevelamer in the presence of added dietary inorganic phosphate or 1α-(OH) D3 for 10 days starting on day 0 and then plasma phosphate was determined. abcMeans with different letter superscripts are different, P < .007. Main effects: D, P < .0001; Sev, P < .0025; interaction NS. Sev, sevelamer hydrochloride; D, 1α-(OH) D3, Pi, added inorganic phosphate balanced with calcium. Journal of Renal Nutrition 2013 23, 21-27DOI: (10.1053/j.jrn.2011.12.005) Copyright © 2013 National Kidney Foundation, Inc. Terms and Conditions