Fresh venous allografts in peripheral arterial reconstruction in dogs

Slides:

Advertisements

Similar presentations

Development and regression of intimal thickening of arterially transplanted autologous vein grafts in dogs Kazumasa Morinaga, M.D., Hiroshi Eguchi, M.D.,

Advertisements

Pulmonary thromboendarterectomy for chronic thromboembolic obstruction of the pulmonary artery in piglets Elie Fadel, MD, Jean Yves Riou, MD, Michel.

Shunya Shindo, M. D. , Atsuhiko Takagi, M. D. , Anthony D

Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh Norihito Okumura, MD, Tatsuo Nakamura, MD, Tohru Natsume, MD, Kenji.

Natural history, duplex characteristics, and histopathologic correlation of arterial injuries in a canine model Thomas F. Panetta, MD, Clifford M. Sales,

David D. Yuh, MD, Kimberly L. Gandy, MD, Bruce A

Bioengineered vascular access maintains structural integrity in response to arteriovenous flow and repeated needle puncture Bryan W. Tillman, MD, PhD,

Wound healing around and within saphenous vein bypass grafts

Comparison of the effect of monopolar and bipolar cauterization on skeletonized, dissected internal thoracic arteries Hiroki Yoshida, MD, Moses Hong-De.

Tissue soldering by use of indocyanine green dye-enhanced fibrinogen with the near infrared diode laser Mehmet C. Oz, MD, Jeffrey P. Johnson, BSE, Sareh.

Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential Lorenzo Boni, MD,

Antidonor humoral transfer induces transplant arteriosclerosis in aortic and cardiac graft models in rats Bassam Alkhatib, MD, Caroline Freguin-Bouilland,

Central venous catheter failure is induced by injury and can be prevented by stabilizing the catheter tip Ted R. Kohler, MD, Thomas R. Kirkman, BS Journal.

Development of a “leak-proof,” knitted Dacron vascular prosthesis

Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches Eric J. Lehr, MD, PhD, Gina R. Rayat, PhD, Brian Chiu, MD, Thomas.

Free flap valvular transplantation for refractory venous ulceration

A novel bioengineered small-caliber vascular graft incorporating heparin and sirolimus: Excellent 6-month patency Yosuke Ishii, MD, Shun-ichiro Sakamoto,

Endothelial sodding of the permaflow prosthetic coronary artery bypass conduit Michael R Phillips, MD, Hiroki Yamaguchi, MD, Virginia M Miller, PhD, Stuart.

Long-term patency of small-diameter vascular graft made from fibroin, a silk-based biodegradable material Soichiro Enomoto, MD, PhD, Makoto Sumi, MD,

Influence of endothelial cell seeding on platelet deposition and patency in small- diameter Dacron arterial grafts Brent T. Allen, M.D., Julie A. Long,

Compound polyglactin 910/polypropylene small vessel prostheses

Harry L. Bush, M. D. , Joseph A. Jakubowski, Ph. D. , G

Makoto Hashizume, M. D. , Ph. D. , Yeng Yang, M. D. , Spencer Galt, M

Nitric oxide–releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts Paul S. Fleser, MD, Vijay K. Nuthakki,

Optimal dose of basic fibroblast growth factor for long-segment orthotopic tracheal autografts Ryoichi Nakanishi, MD, Nobuyuki Nagaya, MD, Takashi Yoshimatsu,

Duplex ultrasound changes in the great saphenous vein after endosaphenous laser occlusion with 808-nm wavelength Leonardo Corcos, MD, Sergio Dini, MD,

J. A. C. Buckels, M. D. , F. R. C. S. , A. G. Nordestgaard, M. D. , S

Thrombosis with outflow obstruction delays thrombolysis and results in chronic wall thickening of rat veins Klaus See-Tho, MD, E.John Harris, MD Journal.

Favorable scanning electron microscopic findings of stapled saphenous vein–carotid artery anastomoses Mohammad Bashar Izzat, Anthony P.C Yim, MD, Kenny.

Experimental study of a new sutureless intraluminal graft with a shape-memory alloy ring Chuanrui Yang, MD, Yanqing Sun, MD, Peiqing Dong, MD, Huazhong.

Conformational stress and anastomotic hyperplasia

The pathology of fresh and cryopreserved homograft heart valves: An analysis of forty explanted homograft valves David R. Koolbergen, MD, Mark G. Hazekamp,

Hiromichi Miwa, MD, Takehisa Matsuda, PhD Journal of Vascular Surgery

A self-renewing, tissue-engineered vascular graft for arterial reconstruction Kei Torikai, MD, Hajime Ichikawa, MD, PhD, Koichiro Hirakawa, MS, Goro Matsumiya,

Differences in reendothelialization after balloon catheter removal of endothelial cells, superficial endarterectomy, and deep endarterectomy Steven G.

The temporal relationship between the development of vein graft intimal hyperplasia and growth factor gene expression John R. Hoch, MD, Vida K. Stark,

The influence of concordant xenografts on the humoral and cell-mediated immune responses to subsequent allografts in primates Robert E. Michler, MDa,

Successful allotransplantation of cryopreserved tracheal grafts with preservation of the pars membranacea in nonhuman primates Tomohiro Murakawa, MD,

Bacterial resistance of refrigerated and cryopreserved aortic allografts in an experimental virulent infection model Pierre-Yves Litzler, MD, Pascale.

Effects of thrombolysis and venous thrombectomy on valvular competence, thrombogenicity, venous wall morphology, and function Jae-Sung Cho, MD, Eugenio.

Dacron inhibition of arterial regenerative activities

Inhibitory effect of methylene blue-induced photooxidation on intimal thickening of vein graft Ke-Xiang Liu, MD, Fumio Yamamoto, MD, Satoshi Sekine,

Xiao J. Feng, MD, PhDa, Cor E. J. Van Hove, b, Paul J

Thomas F. Panetta, MD, Michael L. Marin, MD, Frank J

Use of a bovine jugular vein graft with natural valve for right ventricular outflow tract reconstruction: A one-year animal study Yukio Ichikawa, MD,

Endothelial cell–lined skeletal muscle ventricles in circulation

Rapid cellular luminal coverage of Dacron inferior vena cava prostheses in dogs by immediate seeding of autogenous endothelial cells derived from omental.

Impact of endothelial cell seeding on long-term patency and subendothelial proliferation in a small-caliber highly porous polytetrafluoroethylene graft

Cold ischemia–induced damage to vascular endothelium results in permeability alterations in transplanted lungs M.A. Hidalgo, MDa b, K.A. Shah, MRCPatha,

Biologic degeneration of vein grafts after thrombotic occlusion: thrombectomy within 3 days results in better indices of viability Shigehisa Kawai, MD,

Robert Guidoin, Ph. D. , Henri-Paul Noël, M. D. , Serge Dubé, M. D

A. Simon, DrMeda, M. Wilhelmia, G. Steinhoff, ProfDrMedb, W

Effects of antiplatelet agents in combination with endothelial cell seeding on small- diameter Dacron vascular graft performance in the canine carotid.

Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia Giuseppe R Nigri, MD, PhD, Sylvie.

A comparison of para-anastomotic compliance profiles after vascular anastomosis: Nonpenetrating clips versus standard sutures Mohamed S. Baguneid, FRCSa,

The natural history of microsurgical lymphovenous anastomoses: An experimental study Peter Gloviczki, M.D., Larry H. Hollier, M.D., Frederick E. Nora,

Immunosuppressive treatment of aortic allografts

Human saphenous vein allograft bypass grafts: Immune response

Maj Vikram S. Kashyap, MD, USAF, MCa, Todd D. Reil, MDb, Wesley S

Richard L. Binns, MD Journal of Vascular Surgery

Experimental colonization of a polyester vascular graft with Staphylococcus aureus: A quantitative and morphologic study Catherine Leport, MD, Olivier.

Endothelial cell seeding of a new PTFE vascular prosthesis

Joseph J. Piotrowski, MD, Glenn C. Hunter, MD, Cleamond D

Development of Decellularized Aortic Valvular Conduit Coated by Heparin–SDF-1α Multilayer Jingxin Zhou, PhD, Xiaofeng Ye, MD, PhD, Zhe Wang, MD, Jun.

Critical hand ischemia caused by forearm fibromuscular dysplasia

Neointimal formation at the sites of anastomosis of the internal thoracic artery grafts after coronary artery bypass grafting in human subjects: An immunohistochemical.

Glenn C. Hunter, M.D., Stan N. Carson, M.D.

Ross T. Lyon, M. D. , Arthur Runyon-Hass, Ph. D. , Harry R. Davis, Ph

Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh Norihito Okumura, MD, Tatsuo Nakamura, MD, Tohru Natsume, MD, Kenji.

Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review Alexander W. Clowes, MD, Michael A. Reidy,

Presentation transcript:

Fresh venous allografts in peripheral arterial reconstruction in dogs Eric Wagner, PhDa, Raynald Roy, PhDa, Yves Marois, MScb, Yvan Douville, MD, MScb,c, Robert Guidoin, PhDb The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 6, Pages 1732-1744 (December 1995) DOI: 10.1016/S0022-5223(95)70037-4 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 A, Representative section of autograft explanted at 8 weeks showing normal vein wall structure (Weigert's stain, original magnification × 12.5). B, Untreated histoincompatible allograft biopsied at 2 weeks after transplant showing heavy mononuclear cell infiltration (M) within intima and media,with fibrin (F) deposition onto the luminal surface (original magnification × 25). C, Untreated histoincompatible allograft explanted at 4 weeks with heavy thrombus (T) occluding the luminal surface and markedly reduced cellular infiltration but destruction of intima and disorganization of wall structure (original magnification ×12.5). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 A, Representative section of autograft explanted at 8 weeks showing normal vein wall structure (Weigert's stain, original magnification × 12.5). B, Untreated histoincompatible allograft biopsied at 2 weeks after transplant showing heavy mononuclear cell infiltration (M) within intima and media,with fibrin (F) deposition onto the luminal surface (original magnification × 25). C, Untreated histoincompatible allograft explanted at 4 weeks with heavy thrombus (T) occluding the luminal surface and markedly reduced cellular infiltration but destruction of intima and disorganization of wall structure (original magnification ×12.5). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 A, Representative section of autograft explanted at 8 weeks showing normal vein wall structure (Weigert's stain, original magnification × 12.5). B, Untreated histoincompatible allograft biopsied at 2 weeks after transplant showing heavy mononuclear cell infiltration (M) within intima and media,with fibrin (F) deposition onto the luminal surface (original magnification × 25). C, Untreated histoincompatible allograft explanted at 4 weeks with heavy thrombus (T) occluding the luminal surface and markedly reduced cellular infiltration but destruction of intima and disorganization of wall structure (original magnification ×12.5). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 A, Histologic staining of the only histocompatible allograft that was patent at 20 weeks. Endothelium is well preserved,and moderate intimal thickening (I) is present (original magnification × 12.5). B, MHC-compatible allograft explanted at 16 weeks because of stenosis. Thrombus (T) is present on the luminal surface and important intimal thickening (I) is observed (original magnification × 12.5). C, Allograft from a dog treated with CsA explanted at 5 weeks showing moderate cellular infiltration within intima and media at 5 weeks and unorganized obstructive thrombus (T) lying on the luminal surface (original magnification × 25). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 A, Histologic staining of the only histocompatible allograft that was patent at 20 weeks. Endothelium is well preserved,and moderate intimal thickening (I) is present (original magnification × 12.5). B, MHC-compatible allograft explanted at 16 weeks because of stenosis. Thrombus (T) is present on the luminal surface and important intimal thickening (I) is observed (original magnification × 12.5). C, Allograft from a dog treated with CsA explanted at 5 weeks showing moderate cellular infiltration within intima and media at 5 weeks and unorganized obstructive thrombus (T) lying on the luminal surface (original magnification × 25). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 A, Histologic staining of the only histocompatible allograft that was patent at 20 weeks. Endothelium is well preserved,and moderate intimal thickening (I) is present (original magnification × 12.5). B, MHC-compatible allograft explanted at 16 weeks because of stenosis. Thrombus (T) is present on the luminal surface and important intimal thickening (I) is observed (original magnification × 12.5). C, Allograft from a dog treated with CsA explanted at 5 weeks showing moderate cellular infiltration within intima and media at 5 weeks and unorganized obstructive thrombus (T) lying on the luminal surface (original magnification × 25). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Histologic stainings of allografts from dogs treated with CsA and MMF that remained patent for 20 weeks after operation. A, Five-week biopsy specimen of an allograft showing normal wall organization and moderate cellular infiltration (original magnification × 25). B, Allograft explanted at 20 weeks showing organized thrombus (T) over a nonconcentric area of intimal thickening (I) in midportion (original magnification × 12.5). C, Almost unmodified wall structure observed at anastomotic sites of an allograft explanted at 20 weeks after operation (distal portion of graft, original magnification × 12.5). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Histologic stainings of allografts from dogs treated with CsA and MMF that remained patent for 20 weeks after operation. A, Five-week biopsy specimen of an allograft showing normal wall organization and moderate cellular infiltration (original magnification × 25). B, Allograft explanted at 20 weeks showing organized thrombus (T) over a nonconcentric area of intimal thickening (I) in midportion (original magnification × 12.5). C, Almost unmodified wall structure observed at anastomotic sites of an allograft explanted at 20 weeks after operation (distal portion of graft, original magnification × 12.5). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Histologic stainings of allografts from dogs treated with CsA and MMF that remained patent for 20 weeks after operation. A, Five-week biopsy specimen of an allograft showing normal wall organization and moderate cellular infiltration (original magnification × 25). B, Allograft explanted at 20 weeks showing organized thrombus (T) over a nonconcentric area of intimal thickening (I) in midportion (original magnification × 12.5). C, Almost unmodified wall structure observed at anastomotic sites of an allograft explanted at 20 weeks after operation (distal portion of graft, original magnification × 12.5). L, Luminal surface. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 SEM examination. A, Explanted autograft showing confluent endothelial-like cell lining in midportion of graft (original magnification × 200). B, Proximal region of a thrombosed untreated histoincompatible allograft explanted at 4 weeks with partial colonization by endothelial-like cells and exposition of subendothelium to blood flow (original magnification × 200). C, Midportion of an allograft denuded of ECs, with deposition of thrombotic material onto the luminal surface (original magnification × 200). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 SEM examination. A, Explanted autograft showing confluent endothelial-like cell lining in midportion of graft (original magnification × 200). B, Proximal region of a thrombosed untreated histoincompatible allograft explanted at 4 weeks with partial colonization by endothelial-like cells and exposition of subendothelium to blood flow (original magnification × 200). C, Midportion of an allograft denuded of ECs, with deposition of thrombotic material onto the luminal surface (original magnification × 200). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 SEM examination. A, Explanted autograft showing confluent endothelial-like cell lining in midportion of graft (original magnification × 200). B, Proximal region of a thrombosed untreated histoincompatible allograft explanted at 4 weeks with partial colonization by endothelial-like cells and exposition of subendothelium to blood flow (original magnification × 200). C, Midportion of an allograft denuded of ECs, with deposition of thrombotic material onto the luminal surface (original magnification × 200). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 Scanning electron micrographs (original magnification × 200) of allograft retrieved at 20 weeks from a dog that was treated with CsA and MMF. Anastomotic regions showed almost complete covering of luminal surface with endothelial-like cells without fibrin or thrombotic matrix deposition (A), whereas midportion revealed presence of endothelial-like cells along with thin fibrin (F) deposition (B). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 Scanning electron micrographs (original magnification × 200) of allograft retrieved at 20 weeks from a dog that was treated with CsA and MMF. Anastomotic regions showed almost complete covering of luminal surface with endothelial-like cells without fibrin or thrombotic matrix deposition (A), whereas midportion revealed presence of endothelial-like cells along with thin fibrin (F) deposition (B). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1732-1744DOI: (10.1016/S0022-5223(95)70037-4) Copyright © 1995 Mosby, Inc. Terms and Conditions