The history of EMT in cancer.

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The history of EMT in cancer. The history of EMT in cancer. A. Betty Hay coined the term ‘epithelial to mesenchymal transformation’ (Hay, 1968) and described the transient nature of this process, as well as the reversion to the epithelial character (MET, Hay, 1991). Modified from Acloque et al (2008). B. More than 100 years ago Santiago Ramón y Cajal drew and described the morphological appearance of breast carcinoma so accurately that we can find what we believe to be the first description of EMT (see text). Drawings are adapted from figs. 53 and 48 in Ramon y Cajal (1890). Note the morphology of the cell highlighted as ‘b’. C. At the turn of the 20th century, Hugo Apolant also clearly represented the morphology of EMT‐type mouse mammary tumours (Apolant, 1906). The micrograph shows the distribution of cytokeratin 8/18 in both the epithelial and spindle cell populations in a mouse mammary tumour diagnosed as EMT‐type. This picture is courtesy of Dr P. Damonte and Dr R. Cardiff, Univ. California at Davis. Jose Miguel López‐Novoa, and M. Angela Nieto EMBO Mol Med. 2009;1:303-314 © as stated in the article, figure or figure legend