Key functions of innate lymphoid cells in resolution of inflammation in asthma. a) Natural killer (NK) cells and b) type 2 innate lymphoid cells (ILC2s)

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Key functions of innate lymphoid cells in resolution of inflammation in asthma. a) Natural killer (NK) cells and b) type 2 innate lymphoid cells (ILC2s) express the pro-resolving receptors ALX/FPR2 for lipoxin A4 (LXA4) and CMKLR1 (Chemokine-like receptor 1... Key functions of innate lymphoid cells in resolution of inflammation in asthma. a) Natural killer (NK) cells and b) type 2 innate lymphoid cells (ILC2s) express the pro-resolving receptors ALX/FPR2 for lipoxin A4 (LXA4) and CMKLR1 (Chemokine-like receptor 1) for resolvin E1 (RvE1). LXA4 inhibits NK cell cytotoxicity and increases eosinophil-induced apoptosis by NK cells, and inhibits interleukin (IL)-13 release by ILC2s. RvE1 increases airway eosinophilia and antigen (Ag)-specific CD4+ T-cell clearance. Cindy Barnig, and Bruce D. Levy Eur Respir Rev 2015;24:141-153 ©2015 by European Respiratory Society