Interleukin-6 participation in pathology of ocular diseases

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Interleukin-6 participation in pathology of ocular diseases Forouhe Zahir-Jouzdani, Fatemeh Atyabi, Nazanin Mojtabavi Pathophysiology Volume 24, Issue 3, Pages 123-131 (September 2017) DOI: 10.1016/j.pathophys.2017.05.005 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 IL6 cellular pathways, IL-6 induces homodimerization of gp130 then activates JAK family tyrosine kinases, JAKs induce tyrosine phosphorylation of gp130 and recruitment of STAT3 via the SH2 domain. Followed by phosphorylation of STAT3 by JAKs, it will translocate into the nucleus to regulate gene activation. Pathophysiology 2017 24, 123-131DOI: (10.1016/j.pathophys.2017.05.005) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig 2 IL6 induces ocular neovascularization. Pathophysiology 2017 24, 123-131DOI: (10.1016/j.pathophys.2017.05.005) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 IL6 has roles in the pathogenesis of many ocular disease. Pathophysiology 2017 24, 123-131DOI: (10.1016/j.pathophys.2017.05.005) Copyright © 2017 Elsevier B.V. Terms and Conditions