Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: Effects of single allergen challenge Adriaan.

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Presentation transcript:

Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: Effects of single allergen challenge Adriaan Holm, MD, PhDa, Mariska Dijkstra, MDa, Alex Kleinjan, BSca, Lies-anne Severijnena, Simone Boksa, Paul Mulder, PhDb, Wytske Fokkens, MD, PhDa Journal of Allergy and Clinical Immunology Volume 107, Issue 4, Pages 627-633 (April 2001) DOI: 10.1067/mai.2001.113520 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Schematic chart of the study design. After 6 weeks of fluticasone propionate or placebo treatment, an allergen challenge was performed. Each patient underwent 5 nasal biopsies: at baseline; after 4 weeks of treatment (2 weeks before allergen challenge); 1 hour after challenge with grass pollen; 24 hours after allergen challenge; and 1 week after allergen challenge. Journal of Allergy and Clinical Immunology 2001 107, 627-633DOI: (10.1067/mai.2001.113520) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Cell counts per square millimeter in the nasal epithelium at the 5 biopsy moments (1 , baseline; 2 , after 4 weeks of treatment [2 weeks before provocation]; 3 , 1 hour after provocation with grass pollen; 4 , 24 hours after provocation; and 5 , 1 week after provocation) during the study period (filled bars , fluticasone propionate; open bars , placebo). Results are expressed as medians, interquartile ranges, and the 2.5 and 97.5 percentiles. Journal of Allergy and Clinical Immunology 2001 107, 627-633DOI: (10.1067/mai.2001.113520) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Cell counts per square millimeter in the nasal lamina propria at the 5 biopsy moments (1, baseline; 2, after 4 weeks of treatment [2 weeks before provocation]; 3, 1 hour after provocation with grass pollen; 4, 24 hours after provocation; and 5, 1 week after provocation) during the study period (filled bars , fluticasone propionate; open bars , placebo). Results are expressed as medians, interquartile ranges, and the 2.5 and 97.5 percentiles. Journal of Allergy and Clinical Immunology 2001 107, 627-633DOI: (10.1067/mai.2001.113520) Copyright © 2001 Mosby, Inc. Terms and Conditions