Figure 1 Tau promotes neuronal hypoactivity, even in the absence of tangles. (A) Schematic of the experimental ... Figure 1 Tau promotes neuronal hypoactivity,

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Figure 1 Tau promotes neuronal hypoactivity, even in the absence of tangles. (A) Schematic of the experimental ... Figure 1 Tau promotes neuronal hypoactivity, even in the absence of tangles. (A) Schematic of the experimental approach of Marinković et al., which combined injection of tau fibrils into the cortex of tau-overexpressing P301S mice with in vivo multiphoton GCaMP6s calcium imaging. Tangle-bearing mice (right panel in B and C) were compared to wild-type mice (left) and P301S mice injected with buffer (middle). (B) Spontaneous activity of layer 2/3 cortical neurons is suppressed (indicated by blue colour) in tau overexpressing P301S mice with and without tangles (middle and right). Further analysis did not detect differences in the activity status of tangle-bearing and tangle-free neurons (right). (C) Neuronal activity status remained unchanged over a 10-week recording period. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, Volume 142, Issue 4, 29 March 2019, Pages 843–846, https://doi.org/10.1093/brain/awz060 The content of this slide may be subject to copyright: please see the slide notes for details.