Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease Z. Gordon Jiang, Bynvant.

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Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease Z. Gordon Jiang, Bynvant Sandhu, Linda Feldbrügge, Eric U. Yee, Eva Csizmadia, Shuji Mitsuhashi, Jinhe Huang, Nezam H. Afdhal, Simon C. Robson, Michelle Lai Clinical Gastroenterology and Hepatology Volume 16, Issue 7, Pages 1170-1172 (July 2018) DOI: 10.1016/j.cgh.2017.11.028 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 (A) A schematic diagram of extracellular ADP metabolism shows the 3 enzymatic steps measured in this study. (B) The serum activity of ADA2 increases with the stage of liver fibrosis in NAFLD (***P < .001). (C) An immunohistochemistry of ADA2 in a liver biopsy with stage 4 fibrosis. Scale bar: 50 μm. (D) Receiver operating curve analysis comparing the predictive value of serum ADA2 activity (black) for liver fibrosis with established fibrosis indices: FIB4 (blue), NFS (red), and APRI (green). APRI, AST to Platelet Ratio Index; AUROC, area under the receiver operating curve; ENTPD, ectonucleoside triphosphate diphosphohydrolase; FIB4, Fibrosis-4; NFS, NAFLD Fibrosis Score; 5′-NT, 5’-nucleotidase. Clinical Gastroenterology and Hepatology 2018 16, 1170-1172DOI: (10.1016/j.cgh.2017.11.028) Copyright © 2018 AGA Institute Terms and Conditions