Evaluation of Initial Telomere Length and Changes after Transplantation in Adult Double-Unit Cord Blood Transplant Recipients Beth Ashbridge, Ahmet Zehir,

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Presentation transcript:

Evaluation of Initial Telomere Length and Changes after Transplantation in Adult Double-Unit Cord Blood Transplant Recipients Beth Ashbridge, Ahmet Zehir, Marissa Lubin, Juliet N. Barker, Malcolm A.S. Moore Biology of Blood and Marrow Transplantation Volume 21, Issue 7, Pages 1334-1336 (July 2015) DOI: 10.1016/j.bbmt.2015.04.006 Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Bar chart to show the TL in kb for each CB unit of 13 patients from the day of transplantation (day 0) to last follow-up. Patients were analyzed up to 1 year after transplantation or death (3 patients died before 1 year). The unit with the higher infused viable CD34+ dose per kilogram recipient body weight is indicated with a + sign above the unit on day 0. (A) In 9 patients demonstrating complete single-unit dominance from 28 days after CBT, the unit responsible for sustained donor hematopoiesis is indicated in green whereas nonengrafting units are shown in red. Only 1 patient with complete unit dominance demonstrated TL maintenance after transplantation with a mean percentage TL gain of 11.5% (indicated with the asterisk). (B) Unit TL in 2 patients who displayed initial mixed chimerism but ultimate unit dominance (indicated in green). The proportions represent the contribution of each unit at that time point with the grey indicating a transient contribution of host hematopoiesis. (C) TL in 2 patients with complete donor engraftment but persistent mixed chimerism at 1 year after CBT. Given the units coengrafted and clear unit dominance could not assigned, they are indicated in light and dark blue. Biology of Blood and Marrow Transplantation 2015 21, 1334-1336DOI: (10.1016/j.bbmt.2015.04.006) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions