Volume 4, Issue 1, Pages e21-e30 (January 2017)

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Volume 4, Issue 1, Pages e21-e30 (January 2017) Timing of initiation of antiretroviral therapy and adverse pregnancy outcomes: a systematic review and meta-analysis Olalekan A Uthman, PhD, Prof Jean B Nachega, PhD, Prof Jean Anderson, MD, Steve Kanters, PhD, Edward J Mills, PhD, Françoise Renaud, MD, Shaffiq Essajee, MD, Meg C Doherty, PhD, Lynne M Mofenson, MD The Lancet HIV Volume 4, Issue 1, Pages e21-e30 (January 2017) DOI: 10.1016/S2352-3018(16)30195-3 Copyright © 2017 World Health Organization Terms and Conditions

Figure 1 Summary of evidence search and selection The Lancet HIV 2017 4, e21-e30DOI: (10.1016/S2352-3018(16)30195-3) Copyright © 2017 World Health Organization Terms and Conditions

Figure 2 Forest plot of risk of preterm birth before 37 weeks (prematurity) in women with HIV who initiated ART before conception versus women who initiated ART after conception Error bars are 95% CIs. Area of boxes represents the weight given to the study. The diamond represents the overall pooled effect. The width of the line shows the 95% CIs of the effect estimate of individual studies. The width of the diamond shows the 95% CIs for the overall pooled effect estimate. ART=antiretroviral therapy. The Lancet HIV 2017 4, e21-e30DOI: (10.1016/S2352-3018(16)30195-3) Copyright © 2017 World Health Organization Terms and Conditions

Figure 3 Contour-enhanced funnel plot of publication bias p=0·48 for Egger's regression asymmetry test. The Lancet HIV 2017 4, e21-e30DOI: (10.1016/S2352-3018(16)30195-3) Copyright © 2017 World Health Organization Terms and Conditions

Figure 4 Forest plot of risk of adverse outcomes in women with HIV who initiated ART before conception versus women who initiated ART after conception (and their offspring) Error bars are 95% CIs. Area of boxes represents the weight given to the study. The diamond represents the overall pooled effect. The width of the lines shows the 95% CIs of the effect estimate of individual studies. The width of the diamond shows the 95% CIs for the overall pooled effect estimate. ART=antiretroviral therapy. The Lancet HIV 2017 4, e21-e30DOI: (10.1016/S2352-3018(16)30195-3) Copyright © 2017 World Health Organization Terms and Conditions