Excessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium Guneet Makkar, Ph.D., Ernest.

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Excessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium Guneet Makkar, Ph.D., Ernest Hung Yu Ng, M.D., William Shu Biu Yeung, Ph.D., Pak Chung Ho, M.D. Fertility and Sterility Volume 91, Issue 4, Pages 1145-1151 (April 2009) DOI: 10.1016/j.fertnstert.2008.01.039 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Immunohistochemical expression of interleukin-2 (upper panels) and interferon-γ (lower panels) in human endometrial biopsy samples (magnification, ×630) from three groups of women and a negative control. The paraffin sections of peri-implantation endometrium were stained with monoclonal anti-human IL-2 antibody and with anti-human IFN-γ antibody. Peroxidase activity was visualized by application of diaminobenzidine tetrahydrochloride substrate and counterstained with hematoxylin. Glandular and stromal IL-2 expression were significantly higher in excessive responders compared with in moderate responders and in those from natural cycles. Interferon-γ expression in the glandular and stromal compartments was similar among the three groups. Fertility and Sterility 2009 91, 1145-1151DOI: (10.1016/j.fertnstert.2008.01.039) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions