Volume 155, Issue 2, Pages 245-251 (August 2018) Are We Close to Targeting Enteric Glia in Gastrointestinal Diseases and Motility Disorders?  Brian D. Gulbransen  Gastroenterology  Volume 155, Issue 2, Pages 245-251 (August 2018) DOI: 10.1053/j.gastro.2018.06.050 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Enteric glia are a critical cell type that contributes to health and disease. Glia contribute to integrated gut functions such as motility and are potentially also involved in a number of other physiologic gut processes such as those listed surrounding the glial cell in the diagram. Red arrows point to some of the known conditions where glia are altered by, and contribute to, gut disease and pathophysiology. Areas where glial contributions are better defined are denoted by bold black text, whereas areas where the roles of glia are less clear are listed in gray italicized text. Gastroenterology 2018 155, 245-251DOI: (10.1053/j.gastro.2018.06.050) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Candidate enteric glial therapeutic targets near clinical implementation. Several key glial, and downstream neuronal, mechanisms are illustrated and current strategies to modify function (green, activate; red, antagonize), needs to advance translation of the target and/or drug, and potential clinical benefits are denoted. Gastroenterology 2018 155, 245-251DOI: (10.1053/j.gastro.2018.06.050) Copyright © 2018 AGA Institute Terms and Conditions