Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial.

Slides:

Advertisements

Similar presentations

The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications Jih-Shiuan Wang, MD, Dominique.

Advertisements

From: Transient Hyperglycemia Affects the Extent of Ischemia-Reperfusion-induced Renal Injury in Rats Anesthes. 2008;108(3): doi: /ALN.0b013e318164cff8.

Vascular endothelial growth factor-C derived from CD11b+ cells induces therapeutic improvements in a murine model of hind limb ischemia Go Kuwahara,

Heat shock protein 27: Induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vitro David Mauchley, MD,

Persistent plasminogen activator inhibitor 1 gene expression in cardiac transplant recipients with idiopathic dilated cardiomyopathy Romana Schäfer,

B. Zane Atkins, MD, Scott C. Silvestry, MD, Ravi N. Samy, MD, Ashish S

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure Daniel Zimpfer, MD, Seyedhossein.

Differential expression of Hedgehog/Notch and transforming growth factor-β in human abdominal aortic aneurysms Adam J. Doyle, MD, Eileen M. Redmond,

Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine–induced injury in human internal thoracic.

Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress Munir Boodhwani,

Altered coronary microvascular serotonin receptor expression after coronary artery bypass grafting with cardiopulmonary bypass Michael P. Robich, MD,

Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia- Reperfusion Injury in Diabetic Rats Juchen Li, MD, Yixing Ren, MD,

Circulating microparticles from patients with valvular heart disease and cardiac surgery inhibit endothelium-dependent vasodilation Li Fu, MD, Xiao-Xia.

Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation Hongliang Cong, MD,

Angiogenic response induced by mechanical transmyocardial revascularization Victor Chu, MDa, Jin-qiang Kuang, MDa, Amy McGinna, Adel Giaid, PhDb, Stephen.

Neel R. Sodha, MD, Frank W. Sellke, MD

Simvastatin pretreatment enhances ischemia-induced neovascularization and blood flow recovery in streptozotocin-treated mice Po-Hsun Huang, MD, PhD,

Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity Motohisa Tofukuji, MD, PhD, Alon Stamler,

Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium Michael P. Robich, MD, MSPH, Louis M. Chu, MD,

Nonischemic myocardial acidosis adversely affects microvascular and myocardial function and triggers apoptosis during cardioplegia Kamal R. Khabbaz,

Improved profile of bad phosphorylation and caspase 3 activation after blood versus crystalloid cardioplegia Jun Feng, MD, PhD, Cesario Bianchi, MD,

A new approach: Ischemic mitral regurgitation guidelines by and for surgeons Patrick M. McCarthy, MD The Journal of Thoracic and Cardiovascular Surgery

Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia Ashraf A. Sabe, MD, Brittany.

Intracellular free calcium accumulation in ferret vascular smooth muscle during crystalloid and blood cardioplegic infusions Motohisa Tofukuji, MD, PhDa,

Pediatric pacemaker infections: Twenty years of experience

Moderate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72 Ma Qing, MD, Jaime F. Vazquez-Jimenez,

Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome Nassrene Y. Elmadhun, MD, Antonio D.

Occult active giant cell aortitis necessitating surgical repair

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa,

Cardiopulmonary bypass, myocardial management, and support techniques Changes in autonomic response of the cerebral circulation after normothermic extracorporeal.

Support Your Specialty

Carney's triad paragangliomas

It's not “just a shunt” but sometimes it should be…

Vascular endothelial growth factor and basic fibroblast growth factor in children with cyanotic congenital heart disease Sandra L. Starnes, MDa, Brian.

Munir Boodhwani, MD, William E

Human angiopoietin gene expression is a marker for severity of pulmonary hypertension in patients undergoing pulmonary thromboendarterectomy Patricia.

The role of oxidative stress in the development of pulmonary arteriovenous malformations after cavopulmonary anastomosis Sunil P. Malhotra, MD, V.Mohan.

Cavopulmonary anastomosis induces pulmonary expression of the angiotensin II receptor family Sunil P. Malhotra, MD, V.Mohan Reddy, MD, Stephan Thelitz,

Daniel T. Engelman, MD, FACS, Michael J. Germain, MD

Fueling the heart: Shifting the myocardial metabolome by targeting endothelial autophagy Nicholas D. Andersen, MD The Journal of Thoracic and Cardiovascular.

Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs Marc L. Schermerhorn,

Preconditioning improves cardioplegia-related coronary microvascular smooth muscle hypercontractility: Role of KATP channels Naruto Matsuda, MD, PhDa,

Subodh Verma, MD, PhDa, Fina Lovren, PhDb, Aaron S

Mesenteric dysfunction after cardiopulmonary bypass: role of complement C5a Motohisa Tofukuji, MD, PhD, Gregory L Stahl, PhD, Caroline Metais, MD, Mikio.

O. S. Breathnach, MDa, D. J. Kwiatkowski, MD, PhDb, D. M

Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: Reversal by means.

Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms Bernice Lai Yee Cheuk,

Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig Motohisa Tofukuji, MD, PhD, Caroline Metais, MD, Charles D Collard,

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Munir Boodhwani, MD, MMSc, Neel R

Tai Ji: The law of inflammatory response

Vascular endothelial cell growth factor and fibroblast growth factor 2 expression in patients with critical limb ischemia Ulrika Palmer-Kazen, MD, David.

The future of cardiac surgery training: A survival guide

Outcomes after surgery for thoracic outlet syndrome

High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine

Building a clinical program in a single institution

Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined.

Acute aortic occlusion – Factors that influence outcome

Monitoring vascular surgical performance

“The more things change…”: The challenges ahead

Commentary: Judgment day: Should you add atrial fibrillation ablation?

Thomas J. Kirby, MDa (by invitation), Michael J

Myocardial protection by ischemic preconditioning and δ-opioid receptor activation in the isolated working rat heart Matthias Karck, MDa, Satonori Tanaka,

Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know Harold L. Lazar,

Toll-like receptor 4 inhibition attenuates ischemia-reperfusion injury in rats: Will it work in human beings? Chadrick E. Denlinger, MD The Journal.

Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent.

Of mice and men… The Journal of Thoracic and Cardiovascular Surgery

Hideki Itano, MDa, Bassem N. Mora, MDa, Wanjiang Zhang, MDa, Jon H

Acquired aortopulmonary fistula in acute dissection

Presentation transcript:

Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia Xunyu Xu, MDa, Jian Li, MD, PhDb, Michael Simons, MDb, Jianyi Li, MB, MSa, Roger J. Laham, MDb, Frank W. Sellke, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 121, Issue 4, Pages 735-742 (April 2001) DOI: 10.1067/mtc.2001.112340 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 A, mRNA expression of VEGF and its receptors VEGF-R1 and VEGF-R2, FGF2 and its receptor FGFR-1, and loading control glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in human atrial tissue from the nonischemic (control) and ischemic groups, as analyzed with reverse transcriptase PCR. Positions and sizes of the PCR products in base pairs (bp) are shown at the right. B, Quantitative analysis of mRNA level of expression of VEGF, VEGF-R1, VEGF-R2, FGF2, and FGFR-1 in atrial tissue in the control group (n = 16) and the acute ischemia group (n = 16) indexed as the percentage of density ratio to control specimens (100% expression in nonischemic microvessels). Data are expressed as means ± SD. *P <.05 versus control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 735-742DOI: (10.1067/mtc.2001.112340) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 A, Protein expression of VEGF, VEGF-R1, VEGF-R2, FGF2, FGFR-1, and of loading control Commassie blue in human atrium from the nonischemic (control) and ischemic groups, as analyzed with Western blotting. Positions and sizes of the blotting bands in kilodaltons are shown at the right. B, Quantitative analysis of protein expression of VEGF, VEGF-R1, VEGF-R2, FGF2, and FGFR-1 in atrial microvessels in the control (n = 16) and acute ischemia (n = 16) groups indexed as the percentage of density ratio to control specimens (100% expression in nonischemic microvessels). Data are expressed as means ± SD. *P <.05 versus control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 735-742DOI: (10.1067/mtc.2001.112340) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Plot of in vitro response of atrial microvessels to VEGF in the control group (n = 7) and the acute ischemia group (n = 8). Responses are percentage of relaxation of spontaneous contractions, U46619-induced contractions, or both. Data are expressed as mean ± SD. *P <.05 versus control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 735-742DOI: (10.1067/mtc.2001.112340) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Plot of in vitro response of atrial microvessels to FGF2 in the control group (n = 8) and the acute ischemia group (n = 8). Responses are percentage of relaxation of spontaneous contractions, U46619-induced contractions, or both. Data are expressed as means ± SD. *P <.05 versus control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 735-742DOI: (10.1067/mtc.2001.112340) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Plot of in vitro response to substance P of atrial microvessels in the control group (n = 8) and the acute ischemia group (n = 8). Responses are percentage of relaxation of spontaneous contractions, U46619-induced contractions, or both. Data are expressed as means ± SD. *P <.05 versus control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 735-742DOI: (10.1067/mtc.2001.112340) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Plot of in vitro response to sodium nitroprusside (SNP) of atrial microvessels in the control group (n = 7) and the acute ischemia group (n = 8). Responses are percentage of relaxation of spontaneous contractions, U46619-induced contractions, or both. Data are expressed as means ± SD. *P <.05 vs control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 735-742DOI: (10.1067/mtc.2001.112340) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions