Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: Reversal by lifelong antioxidant supplementation Chang-de Zhan, Ram K. Sindhu, Nosratola.

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Presentation transcript:

Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: Reversal by lifelong antioxidant supplementation Chang-de Zhan, Ram K. Sindhu, Nosratola D. Vaziri Kidney International Volume 65, Issue 1, Pages 219-227 (January 2004) DOI: 10.1111/j.1523-1755.2004.00372.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Systolic blood pressure in Wistar Kyoto (WKY) rats and spontaneously hypertensive rat (SHR) groups raised on a regular diet (SHR-R) or antioxidant-fortified diet (SHR-T) obtained at age 6, 8, 12, and 24weeks.N = 6 in each group, P < 0.05, * SHR-R or SHR-T vs. WKY, # SHR-R vs. SHR-T. Kidney International 2004 65, 219-227DOI: (10.1111/j.1523-1755.2004.00372.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 (A) Renal nitrotyrosine abundance, (B) renal malondialdehyde content, (C) and plasma hydrogen peroxide concentration in Wistar Kyoto (WKY) rats and spontaneously hypertensive rat (SHR) groups raised on a regular diet (SHR-R) or antioxidant-fortified diet (SHR-T).N = 6 in each group, *P < 0.05. Kidney International 2004 65, 219-227DOI: (10.1111/j.1523-1755.2004.00372.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Representative Western blots and group data depicting gp91phox, p22phox, p47phox, and p67phox subunit of NAD(P)H oxidase in the renal cortex of Wistar Kyoto (WKY) rats and spontaneously hypertensive rat (SHR) groups raised on a regular diet (SHR-R) or antioxidant-fortified diet (SHR-T).N = 6 in each group, *P < 0.05and**P < 0.01, ***P < 0.001. Kidney International 2004 65, 219-227DOI: (10.1111/j.1523-1755.2004.00372.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Representative Western blots and group data depicting Aα and B subunit of calcineurin in the renal cortex of Wistar Kyoto (WKY) rats and spontaneously hypertensive rat (SHR) groups raised on a regular diet (SHR-R) or antioxidant-fortified diet (SHR-T).N = 6 in each group, *P < 0.05. Kidney International 2004 65, 219-227DOI: (10.1111/j.1523-1755.2004.00372.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 5 Representative Western blots and group data depicting gp91phox, p47phox, p67phox, and nitrotyrosine abundance in the renal cortex of the Wistar Kyoto (WKY) rats fed a regular (WKY-R) or antioxidant-fortified (WKY-T) diet.N = 6 in each group, no significant differences were found. Kidney International 2004 65, 219-227DOI: (10.1111/j.1523-1755.2004.00372.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 6 Representative Western blots and group data depicting protein abundance of clacineurin subunits (PP2BA α and PP2BB) in renal cortex of the Wistar Kyoto (WKY) rats fed a regular (WKY-R) or antioxidant-fortified (WKY-T) diet.N = 6 in each group, no significant differences were found. Kidney International 2004 65, 219-227DOI: (10.1111/j.1523-1755.2004.00372.x) Copyright © 2004 International Society of Nephrology Terms and Conditions