Volume 122, Issue 2, Pages (February 2002)

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Volume 122, Issue 2, Pages 531-544 (February 2002) Biological actions and therapeutic potential of the glucagon-like peptides Daniel J. Drucker Gastroenterology Volume 122, Issue 2, Pages 531-544 (February 2002) DOI: 10.1053/gast.2002.31068 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 Structural organization of proglucagon and the proglucagon-derived peptides. MPGF, major proglucagon-derived fragment. IP, intervening peptide. The specific peptides liberated by posttranslational processing in pancreas vs. intestine are indicated below the proglucagon molecule. The numerals above and below the proglucagon structure denote the relative amino acid positions of the PGDPs within proglucagon. The arrowhead indicates the position of GLP-1 cleavage to generate GLP-17-36amide and GLP-17-37 from GLP-11-37. Gastroenterology 2002 122, 531-544DOI: (10.1053/gast.2002.31068) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 Amino acid sequence alignment of the human proglucagon-derived peptides and lizard exendin-4. Gastroenterology 2002 122, 531-544DOI: (10.1053/gast.2002.31068) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 3 Histological photomicrograph of a H&E-stained cross-section of the murine jejunum following treatment with either saline or the human GLP-2 analogue h[Gly2]-GLP-2 for 6 days as described in Boushey et al.154 Original magnification 40×. Gastroenterology 2002 122, 531-544DOI: (10.1053/gast.2002.31068) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 4 Representation of glucagon-like peptide action in the gastrointestinal tract. GLP-1 and GLP-2 are cosecreted from gut endocrine L cells and act in part via activation of distinct receptors expressed on distal endocrine cells (GLP-1 and GLP-2) or enteric neural populations (GLP-2) in the islets or gut. Gastroenterology 2002 122, 531-544DOI: (10.1053/gast.2002.31068) Copyright © 2002 American Gastroenterological Association Terms and Conditions