Sudarshan Seshadri, PhD, Mariel Rosati, BS, David C

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Presentation transcript:

Regional differences in the expression of innate host defense molecules in sinonasal mucosa Sudarshan Seshadri, PhD, Mariel Rosati, BS, David C. Lin, MD, Roderick G. Carter, BS, James E. Norton, MS, Andrew Wonho Choi, BS, Lydia Suh, BS, Atsushi Kato, PhD, Rakesh K. Chandra, MD, Kathleen E. Harris, BS, Hong Wei Chu, MD, Anju T. Peters, MD, Bruce K. Tan, MD, David B. Conley, MD, Leslie C. Grammer, MD, Robert C. Kern, MD, Robert P. Schleimer, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 5, Pages 1227-1230.e5 (November 2013) DOI: 10.1016/j.jaci.2013.05.042 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Evaluation of expression of antimicrobial mRNA and protein in uncinate and inferior turbinate tissues of healthy human subjects. Total RNA and protein were extracted from uncinate and inferior turbinate tissues of healthy subjects. Expression of mRNA was analyzed by using real-time PCR. Expression of proteins was analyzed by using ELISA. AB/PAS staining was used to observe differences in the presence of glands. Data for panels D (Tieu et al7) and E to H (UT only-Seshadri et al5) are taken from earlier publications as indicated. AB, Alcian blue; NEC, nasal scraping cells; NS, not significant; PAS, periodic acid-Schiff. *P < .05, **P < .01, and ***P < .001 (Mann-Whitney U test). Journal of Allergy and Clinical Immunology 2013 132, 1227-1230.e5DOI: (10.1016/j.jaci.2013.05.042) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Regional differences in the expression of innate host defense molecules in sinonasal mucosa. Journal of Allergy and Clinical Immunology 2013 132, 1227-1230.e5DOI: (10.1016/j.jaci.2013.05.042) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Evaluation of expression of nitric oxide synthase mRNA in uncinate and inferior turbinate tissues of healthy human subjects. Expression of mRNA of NOS1 (nNOS), NOS2 (iNOS), and NOS3 (eNOS) was evaluated by using real-time PCR. Journal of Allergy and Clinical Immunology 2013 132, 1227-1230.e5DOI: (10.1016/j.jaci.2013.05.042) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Immunohistochemical staining for SPLUNC1 and S100A7 in sinonasal tissue. SPLUNC1 (A) and S100A7 (B) immunostaining in uncinate of a control subject. Representative of at least 3 donors per group. Journal of Allergy and Clinical Immunology 2013 132, 1227-1230.e5DOI: (10.1016/j.jaci.2013.05.042) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Alcian blue/periodic acid-Schiff (AB/PAS) staining in sinonasal tissues. AB/PAS staining in uncinate (A) and inferior turbinate (B) of a control subject. Representative of 5 donors per group. Journal of Allergy and Clinical Immunology 2013 132, 1227-1230.e5DOI: (10.1016/j.jaci.2013.05.042) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions