Dendritic Spine Geometry: Functional Implication and Regulation

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Dendritic Spine Geometry: Functional Implication and Regulation Yasunori Hayashi, Ania K. Majewska  Neuron  Volume 46, Issue 4, Pages 529-532 (May 2005) DOI: 10.1016/j.neuron.2005.05.006 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Ca2+ Compartmentalization and Dendritic Spine Geometry during Synaptic Activity Small dendritic spines (left) have relatively larger NMDA currents than AMPA currents, which may be electrophysiologically recorded as “silent” synapses. Ca2+ efflux from the spine is accomplished primarily through Ca2+ extrusion pumps (spine head conductance [gS]) located in the spine head. These spines are predominantly “pumpers,” as the spine neck is narrow and precludes Ca2+ diffusion into the dendrite (spine neck conductance [gN] is low). This results in large, prolonged Ca2+ signals in the spine and little Ca2+ increase in the dendritic shaft. Large dendritic spines (right), such as those observed after potentiation, have proportionally larger AMPA currents than NMDA currents. Ca2+ efflux from the spine head happens through two pathways: Ca2+ extrusion in the spine head (gS) and, due to the large radius of the spine neck, through Ca2+ diffusion in the dendritic shaft (gN). In these spines, Ca2+ increases are more moderate and transient, while dendritic Ca2+ concentrations are observed to change at the spine base. Neuron 2005 46, 529-532DOI: (10.1016/j.neuron.2005.05.006) Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 2 Rapid and Bidirectional Structural Plasticity of the Dendritic Spine A short burst of stimulation, typically inducing LTP, shifts the equilibrium of F-actin/G-actin toward F-actin (right leg). The increased amount of postsynaptic F-actin enlarges the postsynaptic spine and provides a binding site for other proteins. For some proteins, this is sufficient as an activity-dependent delivery mechanism to the postsynapse. For other proteins, synergistic activation of other mechanisms, such as phosphorylation or other posttranslational modifications, are necessary for postsynaptic delivery. In contrast, prolonged low-frequency stimulation, typically inducing LTD, shifts the F-actin/G-actin equilibrium toward G-actin (left leg). This reduces postsynaptic F-actin and, hence, other F-actin binding proteins, resulting in disassembly of the postsynaptic protein complex and a shrinkage of the dendritic spine. This will eventually disrupt anchorage of surface glutamate receptors, leading to loss of synaptic receptors. Other mechanisms, such as dephosphorylation or endocytosis, are likely involved as well. Neuron 2005 46, 529-532DOI: (10.1016/j.neuron.2005.05.006) Copyright © 2005 Elsevier Inc. Terms and Conditions