Microscopic Colitis: Clinical and Pathologic Perspectives Andreas Münch, Cord Langner  Clinical Gastroenterology and Hepatology  Volume 13, Issue 2, Pages 228-236 (February 2015) DOI: 10.1016/j.cgh.2013.12.026 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Incidence of MC in Olmsted County (1985–2011). Figure courtesy of Darrell Pardi (Mayo Clinic). Clinical Gastroenterology and Hepatology 2015 13, 228-236DOI: (10.1016/j.cgh.2013.12.026) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 (A) LC with a significantly increased number of IELs, increased mononuclear inflammation of the lamina propria, and preserved mucosal architecture (original magnification: 100×). (B) High-power view of IELs. Note the degenerative changes of the surface epithelium (original magnification: 250×). Clinical Gastroenterology and Hepatology 2015 13, 228-236DOI: (10.1016/j.cgh.2013.12.026) Copyright © 2015 AGA Institute Terms and Conditions

Figure 3 (A) CC with an amorphous eosinophil subepithelial collagen band, approximately 30-μm thick. Note secondary degenerative changes with typical sloughing of the surface epithelium (original magnification: 100×). (B) Masson trichrome stain (original magnification: 100×) and (C) immunostaining with antibodies directed against tenascin (original magnification: 100×) show the characteristic irregular (jagged) appearance of the collagen band at the lower border. Clinical Gastroenterology and Hepatology 2015 13, 228-236DOI: (10.1016/j.cgh.2013.12.026) Copyright © 2015 AGA Institute Terms and Conditions

Figure 4 Algorithm for the treatment of MC proposed by the European Microscopic Colitis Group.1 6-MP, 6 mercaptopurine. Clinical Gastroenterology and Hepatology 2015 13, 228-236DOI: (10.1016/j.cgh.2013.12.026) Copyright © 2015 AGA Institute Terms and Conditions