Transcranial Doppler velocimetry in aneurysmal subarachnoid haemorrhage: intra- and interobserver agreement and relation to angiographic vasospasm and.

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Transcranial Doppler velocimetry in aneurysmal subarachnoid haemorrhage: intra- and interobserver agreement and relation to angiographic vasospasm and mortality J.M. Staalsø, T. Edsen, B. Romner, N.V. Olsen British Journal of Anaesthesia Volume 110, Issue 4, Pages 577-585 (April 2013) DOI: 10.1093/bja/aes458 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 TCD measurements in controls and patients in relation to angiographic vasospasm. Population means of mean flow velocity recordings. Error bar: ±2 sd. WFNS, World Federation of Neurosurgical Societies SAH grading scale.23 British Journal of Anaesthesia 2013 110, 577-585DOI: (10.1093/bja/aes458) Copyright © 2013 The Author(s) Terms and Conditions

Fig 2 Intra- and interobserver measurements. (a) Intraobserver analysis: scatterplot of observer's first and second measurements. (b) Interobserver analysis: scatterplot of first observer's vs second observer's measurement. (c) Intraobserver analysis: the Bland–Altman plot of paired differences vs averages of points in (a). (d) Interobserver analysis: the Bland–Altman plot of paired differences vs averages of points in (b). Solid line denotes the line of equality. British Journal of Anaesthesia 2013 110, 577-585DOI: (10.1093/bja/aes458) Copyright © 2013 The Author(s) Terms and Conditions

Fig 3 Proportional bias and LoA in TCCD measurements in patients and volunteers. The Bland–Altman plots of ratios between pairwise measurements against averaged pairwise measurements. Proportional bias and LoA as calculated with variance component analysis are depicted as horizontal lines. (a) Intraobserver agreement in controls. (b) Intraobserver agreement in patients. (c) Interobserver agreement in controls. (d) Interobserver agreement in patients. British Journal of Anaesthesia 2013 110, 577-585DOI: (10.1093/bja/aes458) Copyright © 2013 The Author(s) Terms and Conditions

Fig 4 TCCD prediction of angiographic vasospasm and 30 day mortality. (a) Probability of angiographic vasospasm depending on average TCCD values in the time frame of angiography as predicted by logistic regression model (see the Methods section for details); dotted line is equal to 100% minus the bold line. (b) Diagnostic likelihood ratios (or odds) derived from the model probabilities in (a); dotted line is equal to the inverse of the bold line. (c) Probability of 30 day mortality depending on the average TCCD values day 6–10 as predicted by logistic regression model (see the Methods section for details); dotted line is equal to 100% minus the bold line. (d) Diagnostic likelihood ratios (or odds) derived from the model probabilities in (c); dotted line is equal to the inverse of the bold line. Shaded area signifies 95% confidence interval of fit in all panels. British Journal of Anaesthesia 2013 110, 577-585DOI: (10.1093/bja/aes458) Copyright © 2013 The Author(s) Terms and Conditions

Fig 5 ROC curve of MCA flow velocity in prediction of angiographic vasospasm. ROC curve depicting diagnostic performance at various cut-off values of MCA mean flow velocity. A flow velocity above a given cut-off is termed a positive test and a value below a negative test. The sensitivity is the proportion of positives in patients with vasospasm (true-positive rate), whereas the specificity is the proportion of true negatives in patients without vasospasm (true-negative rate). British Journal of Anaesthesia 2013 110, 577-585DOI: (10.1093/bja/aes458) Copyright © 2013 The Author(s) Terms and Conditions