Reengineering the primary body axis by ectopic cWnt signaling Naveen Wijesena, Mark Q. Martindale  Current Biology  Volume 28, Issue 5, Pages R206-R207 (March 2018) DOI: 10.1016/j.cub.2018.01.042 Copyright © 2018 Elsevier Ltd Terms and Conditions

Figure 1 Ectopic activation of cWnt signaling in N. vectensis embryos results in a new oral–aboral axis. (A) Diagram showing the experimental design where cWnt signaling is activated in an ectopic site after inactivation of endogenous cWnt signaling. WMISH of NvSix3 shows the ectopic expression of NvSix3 (black arrowheads). (C,D) In embryos where cWnt signaling is activated in an ectopic site compared with control embryos (B). WMISH of NvSix3 and NvBra shows the ectopic expression of NvBra (white arrowheads) at a site other than the blastopore and NvSix3 (black arrowheads) is expressed opposite the site of NvBra expression (F,G) compared to control embryos (E). Current Biology 2018 28, R206-R207DOI: (10.1016/j.cub.2018.01.042) Copyright © 2018 Elsevier Ltd Terms and Conditions