Volume 85, Issue 2, Pages 238-240 (January 2014) Soluble fms-like tyrosine kinase-1 and atherosclerosis in chronic kidney disease  Friedrich C. Luft  Kidney International  Volume 85, Issue 2, Pages 238-240 (January 2014) DOI: 10.1038/ki.2013.402 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 The VEGF/PlGF receptor is Flt-1, a tyrosine kinase receptor. The shorter splice variant is soluble and can bind agonist, thereby abrogating Flt-1 activation. Kidney International 2014 85, 238-240DOI: (10.1038/ki.2013.402) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Model of the third immunoglobulin domain of sFlt-1 protein. The spatial structure, including the heparin-binding epitopes of sFlt-1, is shown by means of a computer-generated model. A stretch of 10 amino acids from 272–281 that constitutes the major heparin-binding domain is highlighted. (Illustration supplied through the courtesy of Thadhani et al. and publisher.5) Kidney International 2014 85, 238-240DOI: (10.1038/ki.2013.402) Copyright © 2014 International Society of Nephrology Terms and Conditions