Figure 2: | The p53 core domain is shown as a tetramer bound to DNA from two different rotation angles. a | Residues affected by the five most common tumour-associated.

Slides:

Advertisements

Similar presentations

P53 gene mutations in human tumors Greenblatt et al. (1995) Cancer Res. 54: %

Advertisements

P53 gene mutations in human tumors Greenblatt et al. (1995) Cancer Res. 54: %

P247. Figure 9-1 p248 Figure 9-2 p251 p251 Figure 9-3 p253.

P53 has a key role in integrating the cellular responses (pink boxes) to different types of stress (blue boxes). Activation of p53 can result in a number.

Comparison of p53 Structure: Wild type vs. mutant What change in wild type p53 may lead to cancer?

P53 Missense Mutation Cancer. Outline Disease related to p53 Role and regulation pathway Structure of p53 Missense mutation and consequences Experiment’s.

Supplemental Figure 1.A. Frequency of CCND1 aberrations by tumor type. Included primary cancer diagnosis with N ≥ 20. See Supplemental Table 1 for complete.

STAT3 Michael Patel.

Figure 1. Exploring and comparing context-dependent mutational profiles in various cancer types. (A) Mutational profiles of pan-cancer somatic mutations,

Website: Contact No: ID:

Cancer Gene “Worksheet” Due December 9th beginning of class

Two functional states of human CFTR

פחת ורווח הון סוגיות מיוחדות תהילה ששון עו"ד (רו"ח) ספטמבר 2015

The repeat domain of Tau cross-links to α-tubulin.

Structural Basis of DNA Recognition by p53 Tetramers

RAS’s Cloak of Invincibility Slips at Last?

Volume 105, Issue 4, Pages (May 2001)

Volume 22, Issue 2, Pages (February 2014)

Volume 52, Issue 6, Pages (December 2013)

by Eun-Ju Lee, Daniel J. Dykas, Andrew D. Leavitt, Rodney M

A complete functional map of UBE2I

Volume 23, Issue 12, Pages (December 2015)

A | Schematic phylogenetic tree based on the amino acid alignments of conserved middle (MID) and P-element induced wimpy testis (PIWI) domains from eukaryotic.

Modular Recognition of RNA by a Human Pumilio-Homology Domain

Figure 1. Generation of the S250F Aadc mutant mice

Prognostic and Predictive Effect of TP53 Mutations in Patients with Non–Small Cell Lung Cancer from Adjuvant Cisplatin–Based Therapy Randomized Trials: A.

Supriyo Bhattacharya, Nagarajan Vaidehi Biophysical Journal

The MSP domain of MOSPD2 binds the FFAT motif

Structure of the Angiopoietin-2 Receptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition William A. Barton, Dorothea Tzvetkova,

(A) Six missense mutations in six essential genes that are not in annotated functional domains. (A) Six missense mutations in six essential genes that.

Supplemental Figure 1 1 mutation 2 mutations 3 mutations 4 mutations

Figure 1 Somatic and germ-line TP53 mutations in cancer

Hung-Ta Chen, Steven Hahn Cell

Structure of a tRNA Repair Enzyme and Molecular Biology Workhorse

Molecular model of the PTH(1–34)•PTHR1 complex.

Diabetes Mutations Delineate an Atypical POU Domain in HNF-1α

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations

Tetrameric Structure of a Serine Integrase Catalytic Domain

Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

Splitting p63 The American Journal of Human Genetics

Volume 23, Issue 5, Pages (May 2015)

Volume 18, Issue 8, Pages (August 2010)

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Volume 20, Issue 6, Pages (June 2012)

Sequence alignment of PHCCEx domains with secondary structure elements of the Tiam2 PHCCEx domain at the top. Sequence alignment of PHCCEx domains with.

Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug- Specific Resistance Mutations in Cancer Teresa Kaserer, Julian Blagg

ATPase Site Architecture and Helicase Mechanism of an Archaeal MCM

Kay Perry, Young Hwang, Frederic D. Bushman, Gregory D. Van Duyne

Chromatin structure: Linking structure to function with histone H1

Structural Basis for Catalytic Activation of a Serine Recombinase

Volume 15, Issue 2, Pages (February 2007)

Multifunctional Tumor Suppressor

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Volume 114, Issue 3, Pages (February 2018)

Toshiki Yamada, Kevin Strange Biophysical Journal

Crystal Structure of the N-Terminal Domain of Sialoadhesin in Complex with 3′ Sialyllactose at 1.85 Å Resolution A.P. May, R.C. Robinson, M. Vinson,

Volume 99, Issue 3, Pages (August 2010)

Allosteric drugs: thinking outside the active-site box

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

Volume 17, Issue 1, Pages (January 2009)

Crystal Structure of the Flagellar σ/Anti-σ Complex σ28/FlgM Reveals an Intact σ Factor in an Inactive Conformation Margareta K. Sorenson, Soumya S.

A Model for the γδ Resolvase Synaptic Complex

Feng Xu, Kangling Zhang, Michael Grunstein Cell

Volume 24, Issue 3, Pages (March 2016)

Volume 17, Issue 1, Pages (January 2009)

Volume 67, Issue 1, Pages e2 (July 2017)

Volume 61, Pages (August 2016) Phenotypes and Genotypes in Five Children with Congenital Insensitivity to Pain with Anhidrosis Qing-Li Wang, MD,

Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.

No single ALK mutations confer high-level resistance to lorlatinib.

Presentation transcript:

Figure 2: | The p53 core domain is shown as a tetramer bound to DNA from two different rotation angles. a | Residues affected by the five most common tumour-associated missense mutations (Arg273, Arg248, Arg175, Arg245 and Arg282) according to the cBioportal database158, 159, the TP53 website24 and the International Agency for Research on Cancer (IARC) TP53 database25 are highlighted. b | Three p53 cysteine residues (Cys124, Cys182 and Cys277) that are targets for mutant-p53-reactivating compounds PRIMA-1 (Cys124) and PK11007 (Cys182 and Cys277) are highlighted. Figure adapted from RCSB PDB (PDB ID 2AC0) (Ref. 160). Data from Ref. 161.