Suppression of a sister chromatid cohesion-defective mutant, eso1-G799D, by mutations in cohesin releaser, Wpl1. Suppression of a sister chromatid cohesion-defective.

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Suppression of a sister chromatid cohesion-defective mutant, eso1-G799D, by mutations in cohesin releaser, Wpl1. Suppression of a sister chromatid cohesion-defective mutant, eso1-G799D, by mutations in cohesin releaser, Wpl1. (A) Application of the mixture sequencing strategy to eso1-G799D identified extragenic suppressors in wpl1. (B) Distribution of eso1-G799D suppressor mutations in Wpl1. Mutations are enriched in the Wapl domain of Wpl1. (C) Localization of Wpl1 missense mutations (which are conserved) in the structure of Wpl1 human homolog Wapl (Ouyang et al. 2013). Xingya Xu et al. G3 2018;8:1031-1038 ©2018 by Genetics Society of America