Dietary macronutrients modulate hypertrophy and contractility of the detrusor in an experimental model of bladder obstruction Temitope G. Adedeji, Adesoji.

Slides:

Advertisements

Similar presentations

Garlic decreases liver and kidney receptor for advanced glycation end products expression in experimental diabetes Khaled K. Al-Qattan, Mohamed H. Mansour,

Advertisements

Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease Yava L. Jones-Hall, Matthew B.

Volume 16, Issue 2, Pages (August 2009)

Heat Shock Protein Expression in Rat Skeletal Muscle After Repeated Applications of Pulsed and Continuous Ultrasound Ethne L. Nussbaum, PhD, PT, Marius.

Mohan Manu T, T. Anand, Farhath Khanum Pathophysiology

Obesity and obstructive sleep apnea: Or is it OSA and obesity?

Volume 24, Issue 2, Pages (June 2017)

Volume 24, Issue 2, Pages (June 2017)

Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats Mahmoud Hosseini, S. Mohammad.

Volume 24, Issue 2, Pages (June 2017)

Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechin-gallate in streptozotocin-diabetic rats Mehrdad Roghani, Tourandokht.

Volume 21, Issue 3, Pages (September 2014)

Oxidative stress in autism

Ceftriaxone attenuates glutamate-mediated neuro-inflammation and restores BDNF in MPTP model of Parkinson’s disease in rats Baninder Kaur, Atish Prakash

Volume 23, Issue 2, Pages (June 2016)

Volume 18, Issue 4, Pages (September 2011)

Volume 25, Issue 1, Pages (March 2018)

Volume 21, Issue 2, Pages (June 2014)

A. Jimoh, Y. Tanko, A. Ahmed, A. Mohammed, J.O. Ayo Pathophysiology

A.Y Onaolapo, A.A. Adebayo, O.J Onaolapo Pathophysiology

Mobile phone and cordless phone use and the risk for glioma – Analysis of pooled case- control studies in Sweden, 1997–2003 and 2007–2009 Lennart Hardell,

Lunar biological effects and the magnetosphere

Polyphenols modulate calcium-independent mechanisms in human arterial tissue- engineered vascular media Myriam Diebolt, PhD, Karina Laflamme, PhD, Raymond.

Volume 26, Issue 1, Pages (March 2019)

A 7-day high protein hypocaloric diet promotes cellular metabolic adaptations and attenuates lean mass loss in healthy males Matthew Furber, Ana Anton-Solanas,

Volume 23, Issue 4, Pages (December 2016)

Volume 23, Issue 1, Pages (March 2016)

Volume 22, Issue 2, Pages (June 2015)

Role of vitamin C and selenium in attenuation of nicotine induced oxidative stress, P53 and Bcl2 expression in adult rat spleen Marwa A. Ahmed, K.H.

Calcitonin and Omega–3 Fatty Acids Exhibit Antagonistic and Non-Additive Effects in Experimental Diabetes Wale Johnson Adeyemi, Luqman Aribidesi Olayaki

Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia A. Jimoh, Y. Tanko,

Volume 22, Issue 4, Pages (December 2015)

Effect of short term treatment of L-carnitine on tissue ACE activity in streptozotocin- induced diabetic rats Ali M. Sharifi, Behnoush Zare, Morteza Keshavarz,

Michael T. LeVasseur, Neal D. Goldstein, Seth L. Welles

Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3 Asmaa M.S. Gomaa,

Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-κB, IL- 1β production and lipid peroxidation mediataed cell injury Eman.

Volume 15, Issue 1, Pages 1-8 (June 2008)

Volume 26, Issue 1, Pages (March 2019)

L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects M.O. Kehinde, S.I. Ogungbemi, C.N.

Volume 16, Issue 1, Pages 9-13 (June 2009)

Volume 21, Issue 2, Pages (June 2014)

Kasturi Sarkar, Parames C. Sil Pathophysiology

Volume 17, Issue 1, Pages (February 2010)

Volume 19, Issue 4, Pages (September 2012)

Pierre-Yves von der Weid, Mariappan Muthuchamy Pathophysiology

Volume 20, Issue 4, Pages (September 2013)

Catherine J. Hunter, Isabelle G. De Plaen Pathophysiology

Bamidele Victor Owoyele, Opeyemi Gideon Ayilara Pathophysiology

Volume 15, Issue 1, Pages 9-12 (June 2008)

Nehad Abdulgader Shaer Pathophysiology

Interleukin-6 participation in pathology of ocular diseases

Protein kinase C and synaptic dysfunction after cardiac arrest

Volume 16, Issue 1, Pages (June 2009)

David A. Clark, Upender K. Munshi Pathophysiology

Volume 7, Issue 3, Pages (March 2008)

Peripheral brain-derived neurotrophic factor is reduced in stroke survivors with cognitive impairment Tasneem M. Hassan, Isyaku U. Yarube Pathophysiology

Volume 18, Issue 2, Pages (April 2011)

Experimental maternal treatment with dexamethasone during lactation induces neonatal testicular and epididymal oxidative stress; Implications for early.

Volume 26, Issue 1, Pages (March 2019)

Oral contraceptive administration aggravates nitric oxide synthesis inhibition-induced high blood pressure in female rats L.A. Olatunji, A.O. Soladoye

Volume 21, Issue 4, Pages (November 2014)

Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats Hojjatallah.

Skin cancer epidemic in a wireless world

Increasing incidence of brain tumours in sparsely populated areas

The impact of psychogenic stressors on oxidative stress markers and patterns of CYP2E1 expression in mice liver Oksana Maksymchuk, Mykola Chashchyn

The effect of maintenance and reversal of DOCA-Salt hypertension on extravasation of macromolecules and serum nitric oxide concentration in male rats

Volume 25, Issue 1, Pages (March 2018)

Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats L.A. Olatunji, A.O. Soladoye Pathophysiology

Volume 16, Issue 1, Pages (June 2009)

Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner Tetsuya Adachi, MDa, Susan Stafford,

Presentation transcript:

Dietary macronutrients modulate hypertrophy and contractility of the detrusor in an experimental model of bladder obstruction Temitope G. Adedeji, Adesoji A. Fasanmade, Emiola O. Olapade-Olaopa Pathophysiology Volume 26, Issue 1, Pages 11-20 (March 2019) DOI: 10.1016/j.pathophys.2018.12.003 Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 1 Diet-induced changes in bladder weight in unobstructed and obstructed rats’ bladders. Values are mean ± SEM for 10 animals per dietary group. P < 0.05. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 2 Diet-induced changes in detrusor contractile activity in unobstructed and obstructed rats’ bladders. Values are mean ± SEM for 10 animals per dietary group. P < 0.05. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 3 Effects of diet-induced metabolic phenotypes on Rho-kinase I mRNA expression in both unobstructed and obstructed rats’ bladders. Values are mean ± SEM for ten 12-week old male animals per dietary group; P < 0.05. * = significant in comparison with control. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 4 Effects of diet-induced metabolic phenotypes on Rho-kinase II mRNA expression in both unobstructed and obstructed rats’ bladders. Values are mean ± SEM for ten 12-week old male animals per dietary group; P < 0.05. * = significant in comparison with control. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 5 Effects of diet-induced metabolic phenotypes on Myosin light chain kinase mRNA expression in both unobstructed and obstructed rats’ bladders. Values are mean ± SEM for ten 12-week old male animals per dietary group; P < 0.05. * = significant in comparison with control. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 6 Effects of diet-induced metabolic phenotypes on Rho-kinase I Protein expression in both unobstructed and obstructed rats’ bladders. Values are mean ± SEM for ten 12-week old male animals per dietary group; P < 0.05. * = significant in comparison with control. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 7 Effects of diet-induced metabolic phenotypes on Rho-kinase II Protein expression in both unobstructed and obstructed rats’ bladders. Values are mean ± SEM for ten 12-week old male animals per dietary group; P < 0.05. * = significant in comparison with control. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 8 Effects of diet-induced metabolic phenotypes on Myosin Light Chain Protein expression in both unobstructed and obstructed rats’ bladders. Values are mean ± SEM for ten 12-week old male animals per dietary group; P < 0.05. * = significant in comparison with control. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 9 Rho-Kinase I (1), Rho-Kinase II (2) and Myosin Light Chain Kinase (MLCK) (2) Expression respectively from PCR. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 10 Western Blots for Rho-Kinase I (1), Rho-Kinase II (2) and Myosin Light Chain Kinase (MLCK) (3) Expression respectively. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 11 Schematic showing relationship of diet with the Rho-Kinases and Myosin Light Chain Kinase. Pathophysiology 2019 26, 11-20DOI: (10.1016/j.pathophys.2018.12.003) Copyright © 2018 Elsevier B.V. Terms and Conditions