Atropine, Hyoscine Butylbromide, or Scopolamine Are Equally Effective for the Treatment of Death Rattle in Terminal Care  Hans Wildiers, MD, PhD, Chris Dhaenekint, Peter Demeulenaere, MD, Paul M.J. Clement, MD, PhD, Mark Desmet, MD, Rita Van Nuffelen, Jacques Gielen, MD, Erna Van Droogenbroeck, MD, Filip Geurs, MD, Jean-Pierre Lobelle, MD, Johan Menten, MD, PhD  Journal of Pain and Symptom Management  Volume 38, Issue 1, Pages 124-133 (July 2009) DOI: 10.1016/j.jpainsymman.2008.07.007 Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Trial profile. T+1 indicates time point one hour after the start of treatment. T+4 indicates time point four hours after start of treatment. Journal of Pain and Symptom Management 2009 38, 124-133DOI: (10.1016/j.jpainsymman.2008.07.007) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Effectiveness per treatment arm over time. Therapy was considered effective when the intensity of rattle after treatment was 0 or 1, and was considered not effective if the score was 2 or 3. Numbers per bar indicate number of patients. Journal of Pain and Symptom Management 2009 38, 124-133DOI: (10.1016/j.jpainsymman.2008.07.007) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Overall effectiveness of anticholinergic treatment (all patients together) on rattle intensity at baseline and over time. Journal of Pain and Symptom Management 2009 38, 124-133DOI: (10.1016/j.jpainsymman.2008.07.007) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 Overall survival after randomization per treatment arm. Journal of Pain and Symptom Management 2009 38, 124-133DOI: (10.1016/j.jpainsymman.2008.07.007) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions