Mediastinal growing teratoma syndrome after cisplatin-based chemotherapy and radiotherapy for intracranial germinoma Hisashi Iwata, MD, PhD, Yoshio Mori,

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The Growing Teratoma Syndrome

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Mediastinal growing teratoma syndrome after cisplatin-based chemotherapy and radiotherapy for intracranial germinoma Hisashi Iwata, MD, PhD, Yoshio Mori, MD, PhD, Hisato Takagi, MD, PhD, Koyo Shirahashi, MD, Jun Shinoda, MD, PhD, Kuniyasu Shimokawa, MD, PhD, Hajime Hirose, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 127, Issue 1, Pages 291-293 (January 2004) DOI: 10.1016/S0022-5223(03)01300-X

Figure 1 Rapid-growing mediastinal tumor. Tumor doubling time was 34.3 days. A, Chest computed tomographic findings at admission to our department; B, 12 days after admission; C,19 days after admission. The Journal of Thoracic and Cardiovascular Surgery 2004 127, 291-293DOI: (10.1016/S0022-5223(03)01300-X)

Figure 2 Tumor consists of mature squamous epithelium with immature glandular structures (A-1). Mature squamous epithelium stains positively for keratin (A-2). Immature glandular structure (A-3) is less than 10% in the tumor and positive for carcinoembryonic antigen (A-4) but stains negatively for AFP and hCG. Intracranial tumor partially resected before chemoradiotherapy (B) was pure germinoma and negative for AFP and hCG. The Journal of Thoracic and Cardiovascular Surgery 2004 127, 291-293DOI: (10.1016/S0022-5223(03)01300-X)