The Prognostic Significance of Focal Adhesion Kinase Expression in Stage I Non– Small-Cell Lung Cancer Grace K. Dy, MD, Lourdes Ylagan, MD, Saraswati.

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The Prognostic Significance of Focal Adhesion Kinase Expression in Stage I Non– Small-Cell Lung Cancer Grace K. Dy, MD, Lourdes Ylagan, MD, Saraswati Pokharel, MD, Austin Miller, PhD, Elizabeth Brese, BS, Wiam Bshara, MD, Carl Morrison, MD, DVM, William G. Cance, MD, Vita M. Golubovskaya, PhD Journal of Thoracic Oncology Volume 9, Issue 9, Pages 1278-1284 (September 2014) DOI: 10.1097/JTO.0000000000000248 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Immunohistochemical analysis of focal adhesion kinase (FAK) expression in stage I non–small-cell lung cancer tissue microarray (TMA) samples. FAK expression was detected by immunohistochemical staining with FAK 4.47 monoclonal antibody using TMA samples with triplicate tissue cores per tumor stained. Scale bars shown represent 150 micrometers in length. Images taken under ×20 magnification. A, representative images of scoring system that measured intensity (0, none; 1+, weak; 2+, moderate; and 3+, strong). (B) Representative triplicate core showing extent of staining which represented the number of cores with a positive staining (extent 0, no staining in three cores; 1, only one core had a positive staining, mild; 2, only 2 cores had a positive staining, moderate; 3, all three cores had the positive staining, diffuse). In this example, the “extent” score is 3. The total FAK score including the measured intensity is 6. Journal of Thoracic Oncology 2014 9, 1278-1284DOI: (10.1097/JTO.0000000000000248) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Focal adhesion kinase (FAK) staining in normal lung and lung cancer tissue microarray (TMA). (A) Four representative TMA cores with normal and tumor samples are shown and marked as N1–4 and T1–4, respectively. As seen in the upper row, most of the normal lung tissue did not express FAK. In comparison, FAK expression is seen in lung cancer cells (but not in surrounding stromal tissue). Scale bar shown represents 150 micrometers in length. (B) Representative magnified (200×) images derived from N2 and T2 samples in (A) of FAK staining in normal and tumor sample. Journal of Thoracic Oncology 2014 9, 1278-1284DOI: (10.1097/JTO.0000000000000248) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Overall survival rate and Focal adhesion kinase (FAK) expression in stage I non–small-cell lung cancer patients. There is no significant difference between overall survival and FAK expression in lung cancer. Log-rank curve and p values are shown for Figure 3A according to FAK score more than or equal to 3 and less than 3 and for Figure 3B according to FAK score more than or equal to 5 and less than 5. Journal of Thoracic Oncology 2014 9, 1278-1284DOI: (10.1097/JTO.0000000000000248) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions