Volume 134, Issue 2, Pages (July 2008)

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Volume 134, Issue 2, Pages 199-202 (July 2008) The Hunt for Cyclin Peter K. Jackson Cell Volume 134, Issue 2, Pages 199-202 (July 2008) DOI: 10.1016/j.cell.2008.07.011 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 A Simple Experiment In Tim Hunt's classic experiment, fertilized eggs from the sea urchin Arbacia were labeled with radioactive methionine, and extracts were resolved on SDS-polyacrylamide gels. The autoradiograph of the protein gel shows the clear result that one protein, called cyclin, accumulates and is precipitously destroyed in mitosis (Evans et al., 1983). Cell 2008 134, 199-202DOI: (10.1016/j.cell.2008.07.011) Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 2 MPF in 1989 and Today In 1989, cell cycle researchers were stunned by the demonstration that the oscillating protein cyclin activated Cdc2 kinase, resulting in activation of Mitosis Promoting Factor (MPF). Today, there are many biochemical processes involved in the regulation of MPF and mitosis, including cyclin assembly onto Cdc2 kinase, regulation of Cdc2 by tyrosine phosphorylation and by other kinases and phosphatases, and the important regulatory role of protein destruction. Cell 2008 134, 199-202DOI: (10.1016/j.cell.2008.07.011) Copyright © 2008 Elsevier Inc. Terms and Conditions