Volume 131, Issue 2, Pages (August 2006)

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Volume 131, Issue 2, Pages 439-444 (August 2006) Immunohistochemical Expression of MYH Protein Can Be Used to Identify Patients With MYH-Associated Polyposis Carmela Di Gregorio, Milo Frattini, Stefania Maffei, Giovanni Ponti, Lorena Losi, Monica Pedroni, Tiziana Venesio, Lucio Bertario, Liliana Varesco, Mauro Risio, Maurizio Ponz de Leon Gastroenterology Volume 131, Issue 2, Pages 439-444 (August 2006) DOI: 10.1053/j.gastro.2006.05.049 Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 1 Nuclear and cytoplasmic immunoreactivity of MYH protein in colonocytes of normal mucosa (original magnification, 100×). Gastroenterology 2006 131, 439-444DOI: (10.1053/j.gastro.2006.05.049) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 2 Nuclear and weak cytoplasmic expression of MYH protein in sporadic colorectal cancer (original magnification, 40×). Gastroenterology 2006 131, 439-444DOI: (10.1053/j.gastro.2006.05.049) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 3 Nuclear and weak cytoplasmic expression of MYH protein in an adenoma of a FAP patient with APC germline mutation (original magnification, 20×). Gastroenterology 2006 131, 439-444DOI: (10.1053/j.gastro.2006.05.049) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 4 Strong granular cytoplasmic immunohistochemical staining without nuclear expression of MYH protein in (A) adenoma (20×) and (B) carcinoma (original magnification, 20×) of patients with biallelic MYH mutations. Gastroenterology 2006 131, 439-444DOI: (10.1053/j.gastro.2006.05.049) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 5 Strong cytoplasmic immunoreactivity and absence of nuclear expression of MYH protein in normal mucosa of a patient with a biallelic MYH mutation (original magnification, 20×). Gastroenterology 2006 131, 439-444DOI: (10.1053/j.gastro.2006.05.049) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions