EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers Kentaro Inamura, MD, PhD, Kengo Takeuchi, MD, PhD, Yuki Togashi,

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EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers Kentaro Inamura, MD, PhD, Kengo Takeuchi, MD, PhD, Yuki Togashi, MPharm, Kimie Nomura, Hironori Ninomiya, MD, Michiyo Okui, PhD, Yukitoshi Satoh, MD, PhD, Sakae Okumura, MD, Ken Nakagawa, MD, Manabu Soda, MD, PhD, Young Lim Choi, MD, PhD, Toshiro Niki, MD, PhD, Hiroyuki Mano, MD, PhD, Yuichi Ishikawa, MD, PhD Journal of Thoracic Oncology Volume 3, Issue 1, Pages 13-17 (January 2008) DOI: 10.1097/JTO.0b013e31815e8b60 Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 RT-PCR for EML4-ALK fusion mRNA. All the 5 fusion-positive cases and fusion negative cases of all the histologic subtypes examined are shown. RT-PCR results for GAPDH mRNA are also included as an internal control. AC, adenocarcinoma; mixed, adenocarcinoma with mixed subtype; papillary, papillary adenocarcinoma; acinar, acinar adenocarcinoma; solid, solid adenocarcinoma with mucin; BAC, bronchioloalveolar carcinoma; SCC, squamous cell carcinoma; LCNEC, large cell neuroendocrine carcinoma; SCLC, small cell lung carcinoma; NTC, no template control. Journal of Thoracic Oncology 2008 3, 13-17DOI: (10.1097/JTO.0b013e31815e8b60) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Representative examples of histologic features. Both the 2 variant 1 cases were mixed type adenocarcinomas, with papillary and bronchioloalveolar components (A). All 3 variant 2 cases were acinar adenocarcinomas (B). Journal of Thoracic Oncology 2008 3, 13-17DOI: (10.1097/JTO.0b013e31815e8b60) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Representative examples of immunohistochemical features. Both adenocarcinomas with mixed subtype (A) with the variant 1 EML4-ALK fusion and acinar adenocarcinomas (B) with the variant 2 show ALK fusion protein in their cytoplasm. Journal of Thoracic Oncology 2008 3, 13-17DOI: (10.1097/JTO.0b013e31815e8b60) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions