Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK) P.A.J.M. Vos, J. DeGroot,

Slides:

Advertisements

Similar presentations

Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.

Advertisements

Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment: data from the Osteoarthritis Initiative

Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort.

Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee S. Reiter-Niesert, M. Boers, J. Detert

A systematic review of the association between radiographic and clinical osteoarthritis of hip and knee M.B. Kinds, P.M.J. Welsing, E.P. Vignon, J.W.J.

The epidemiology and impact of pain in osteoarthritis

Influence of variation in semiflexed knee positioning during image acquisition on separate quantitative radiographic parameters of osteoarthritis, measured.

The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment T.N.

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis N.H. Lim, E. Meinjohanns, M. Meldal, G.

P.-S. Hsu, H.-H. Lin, C.-R. Li, W.-S. Chung

Disability and quality of life of patients with knee or hip osteoarthritis in the primary care setting and factors associated with general practitioners'

Changes in social isolation and loneliness following total hip and knee arthroplasty: longitudinal analysis of the English Longitudinal Study of Ageing.

Associations between pre-operative radiographic changes and outcomes after total knee joint replacement for osteoarthritis M.M. Dowsey, M. Nikpour, P.

Osteoarthritis as a disease of mechanics

A sex-specific association between incident radiographic osteoarthritis of hip or knee and incident peripheral arterial calcifications: 8-year prospective.

Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK W.E.

No evidence for the effectiveness of a multidisciplinary group based treatment program in patients with osteoarthritis of hands on the short term; results.

B. J. E. de Lange-Brokaar, M. Kloppenburg, S. N. Andersen, A. L

M. K. Kosinska, S. C. Mastbergen, G. Liebisch, J. Wilhelm, R. B

The responsiveness of three-dimensional knee accelerations used as an estimation of knee instability and loading transmission during gait in osteoarthritis.

K.D. Allen, C.J. Coffman, Y.M. Golightly, K.M. Stechuchak, F.J. Keefe

Avoidance of activity and limitations in activities in patients with osteoarthritis of the hip or knee: a 5 year follow-up study on the mediating role.

Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients F.M. Germaschewski, C.J. Matheny, J. Larkin,

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis J.J. McDougall, N. Schuelert, J. Bowyer

M. Stumm, E. Boger, C. G. Gaissmaier, C. Oßwald, M. Blankenburg, R. D

Cross-cultural adaptation and implementation of Good Life with osteoarthritis in Denmark (GLA:D™): group education and exercise for hip and knee osteoarthritis.

Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis F. Bellucci,

L. Shamir, S. M. Ling, W. Scott, M. Hochberg, L. Ferrucci, I. G

Pre-operative interventions (non-surgical and non-pharmacological) for patients with hip or knee osteoarthritis awaiting joint replacement surgery – a.

Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study L.F.D. van Vulpen, M.E.R.

Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation

The course of ultrasonographic abnormalities in knee osteoarthritis: 1 year follow up K. Bevers, J.W.J. Bijlsma, J.E. Vriezekolk, C.H.M. van den Ende,

Comparison of load responsiveness of cartilage T1rho and T2 in porcine knee joints: an experimental loading MRI study H. Hamada, T. Nishii, S. Tamura,

Disease burden of knee osteoarthritis patients with a joint replacement compared to matched controls: a population-based analysis of a Dutch medical claims.

Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by fractal methods P. Podsiadlo, Ph.D., L.

B. F. Riecke, R. Christensen, S. Torp-Pedersen, M. Boesen, H

Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage T.N.

Lisa G. Criscione, M. D. , Alan L. Elliott, M. D. , M. P. H

Time to be positive about negative data?

Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD.

A. Sankar, A. M. Davis, M. P. Palaganas, D. E. Beaton, E. M. Badley, M

Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis.

Diagnostic performance of knee ultrasonography for detecting degenerative changes of articular cartilage S. Saarakkala, P. Waris, V. Waris, I. Tarkiainen,

S. Sonne-Holm, M.D., Dr. Sci., S. Jacobsen, M.D.

Knee Images Digital Analysis (KIDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail A.C.A. Marijnissen,

Feasibility of bone density evaluation using plain digital radiography

In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model F. Intema, H.A.W.

Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain J. Cibere,

Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment: data from the Osteoarthritis Initiative

The course of limitations in activities over 5 years in patients with knee and hip osteoarthritis with moderate functional limitations: risk factors for.

Utilization rates of hip arthroplasty in OECD countries

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis M. Blagojevic, C. Jinks, A. Jeffery, K.P.

Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a randomized controlled trial comparing two different.

Who should have a joint replacement? A plea for more ‘phronesis’

Lack of a clear disease modifying activity of celecoxib in treatment of end-stage knee osteoarthritis: a rondomized observer blinded clinical trial E.M.

Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up

Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous.

D.J. Hunter Osteoarthritis and Cartilage

The association between hip bone marrow lesions and bone mineral density: a cross- sectional and longitudinal population-based study H. Ahedi, D. Aitken,

The canine ‘groove’ model of osteoarthritis is more than simply the expression of surgically applied damage Simon C. Mastbergen, M.Sc., Anne C. Marijnissen,

Instruments to assess physical activity in patients with osteoarthritis of the hip or knee: a systematic review of measurement properties C.B. Terwee,

C. Ratzlaff, M. Koehoorn, J. Cibere, J. Kopec

T. Silvestri, M. D. , L. Pulsatelli, Ph. D. , P. Dolzani, Ph. D. , A

Comparison of the extent to which total hip and total knee arthroplasty restore patient- reported physical function N.A. Glass, N.A. Segal, J.J. Callaghan,

Acute resistance exercise and pressure pain sensitivity in knee osteoarthritis: a randomised crossover trial N.J. Burrows, J. Booth, D.L. Sturnieks,

Osteoarthritis year 2012 in review: biology

Knee cartilage defects in a sample of older adults: natural history, clinical significance and factors influencing change over 2.9 years J. Carnes, O.

Location-specific hip joint space width for progression of hip osteoarthritis – Data from the Osteoarthritis Initiative C. Ratzlaff, C. Van Wyngaarden,

Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria W.E. van Spil, J. DeGroot,

The relationship between foot and ankle symptoms and risk of developing knee osteoarthritis: data from the osteoarthritis initiative K.L. Paterson, J.

Presentation transcript:

Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK) P.A.J.M. Vos, J. DeGroot, A.M. Huisman, J.C.M. Oostveen, A.C.A. Marijnissen, J.W.J. Bijlsma, B. van El, A.M. Zuurmond, F.P.J.G. Lafeber Osteoarthritis and Cartilage Volume 18, Issue 10, Pages 1329-1336 (October 2010) DOI: 10.1016/j.joca.2010.07.006 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 The correlation between cartilage and skin pentosidine. Paired cartilage and skin samples were obtained post mortem of 17 donors. Cartilage was obtained from femoral knee condyles and humeral heads, skin samples were taken from the incision site. Regression coefficient and p value have been provided. Osteoarthritis and Cartilage 2010 18, 1329-1336DOI: (10.1016/j.joca.2010.07.006) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Correlation of skin pentosidine and the summed K&L score of the four joints. The summed K&L score was divided into two groups, no (summed K&L score 0–3; n=173) and mild (summed K&L score 4–12; n=32) radiological OA. Joint with K&L score four were not included. Participants with low radiological OA had a lower skin pentosidine compared to the participants with mild radiological OA (A). Separating the knees (B; summed K&L score 0–1 or 3–6; n=178 and 27, respectively) and hips (C; summed K&L score 0–1 or 3–6; n=138 and 67, respectively) shows that only for the knees this difference is maintained. Median (dash), with the interquartile range (box; 50%) with the fifth and nintyfifth percentiles (whiskers) are presented. (D) The correlation between skin pentosidine and summed K&L score of the two knees (n=205). Spearman correlation coefficient with p value has been provided. Osteoarthritis and Cartilage 2010 18, 1329-1336DOI: (10.1016/j.joca.2010.07.006) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 The correlation between mean urine pentosidine and skin pentosidine of 205 participants. There is a statistically significant correlation between both parameters, with a low correlation coefficient. Osteoarthritis and Cartilage 2010 18, 1329-1336DOI: (10.1016/j.joca.2010.07.006) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Correlation of mean urine pentosidine (A) and urine CTXII levels divided into three groups, low (≤ 0.22μg/mmol; n=65), middle (0.22–0.37μg/mmol; n=66) and high (≥0.37μg/mmol; n=66) CTXII levels. For urine pentosidine all groups were different except the middle and high CTXII group. Median (dash), with the interquartile range (box; 50%) with the fifth and nintyfifth percentiles (whiskers) are presented. Fig. B shows the correlation between urine pentosidine and CTXII levels. A low correlation between these parameters was found (R=0.235, P=0.001; n=200). Osteoarthritis and Cartilage 2010 18, 1329-1336DOI: (10.1016/j.joca.2010.07.006) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions