BRAGging about Mechanisms of Long-Term Depression

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BRAGging about Mechanisms of Long-Term Depression Stephen M. Fitzjohn, Zafar I. Bashir Neuron Volume 66, Issue 5, Pages 627-630 (June 2010) DOI: 10.1016/j.neuron.2010.05.027 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Mechanisms of mGluR-LTD (A) Y876 of the GluA2 subunit is basally phosphorylated, preventing activation of BRAG2. (B) Activation alone of group I mGluRs will stimulate protein tyrosine phosphatase (PTP) to dephosphorylate Y876. However, (C) AMAPR activation is also required for BRAG2 to activate Arf6 which subsequently recruits vesicle-forming proteins to the complex and promotes internalization of AMPARs. Neuron 2010 66, 627-630DOI: (10.1016/j.neuron.2010.05.027) Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 2 Consequences of the Requirement of Both AMPAR and mGluR Activation for LTD Induction (A) At a weakly active synapse AMPARs, but not perisynaptic group I mGluRs, are stimulated by glutamate and LTD is not induced. (B) When a synapse is strongly activated both AMPARs and mGluRs are stimulated and LTD occurs. (C) Glutamate spillover can activate perisynaptic mGluRs. If glutamate spills over from a strongly activated synapse (middle), then LTD will occur at this synapse. However, LTD will also occur at a neighboring synapse that is concurrently only weakly active since both mGluR and AMPARs are stimulated (right). LTD will not be induced at a neighboring inactive synapse as only mGluR but not AMPAR stimulation will occur at this synapse (left). Neuron 2010 66, 627-630DOI: (10.1016/j.neuron.2010.05.027) Copyright © 2010 Elsevier Inc. Terms and Conditions