Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans P. Reinstrup, E. Ryding, T. Ohlsson,

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Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans P. Reinstrup, E. Ryding, T. Ohlsson, A. Sandell, K. Erlandsson, K. Ljunggren, L.G. Salford, S. Strand, T. Uski British Journal of Anaesthesia Volume 100, Issue 1, Pages 66-71 (January 2008) DOI: 10.1093/bja/aem334 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Representative curve from one participant demonstrating the activity of FDG in plasma as a function of time. British Journal of Anaesthesia 2008 100, 66-71DOI: (10.1093/bja/aem334) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Regional CMRglu in the brain through the different regions during inhalation of N2O 50% (in O2 30% in N2), and O2 30% in N2. The results are presented as mean values (sd) (n=7). British Journal of Anaesthesia 2008 100, 66-71DOI: (10.1093/bja/aem334) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 The change in regional CMRglu due to inhalation of N2O 50%. The results are presented in absolute values and as mean values (sd) (n=7). British Journal of Anaesthesia 2008 100, 66-71DOI: (10.1093/bja/aem334) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Representative pictures from scans in one of the volunteers during inhalation of oxygen-enriched air (30% O2) (left pictures) and during inhalation of nitrous oxide (50% N2O) (right pictures). The top figures represent three-dimensional CBF measurements with 133Xe and SPECT from a former study10 and the bottom figures, the cerebral metabolism (CMRglu), from this study, in concomitant situations. British Journal of Anaesthesia 2008 100, 66-71DOI: (10.1093/bja/aem334) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 5 Figure demonstrating the lingering effect on the regional CMRglu when N2O (N2O 50%, O2 30%) was inhaled first followed by oxygen-enriched air (O2 30%) (n=3). British Journal of Anaesthesia 2008 100, 66-71DOI: (10.1093/bja/aem334) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions