Biology of Blood and Marrow Transplantation

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Presentation transcript:

Biology of Blood and Marrow Transplantation Vitamin a and Gastrointestinal Graft Versus Host Disease in Children: Mechanistic Studies Dana T. Lounder, Pooja Khandelwal, Sonata Jodele, Christopher E. Dandoy, Gregory Wallace, Adam Lane, Cynthia B. Taggart, Ashley Teusink-Cross, Kelly E. Lake, Stella M. Davies Biology of Blood and Marrow Transplantation Volume 23, Issue 3, (March 2017) DOI: 10.1016/j.bbmt.2017.01.048 Copyright © 2016 Terms and Conditions

Figure 1 Cumulative incidence of mucosal barrier injury (MBI) bloodstream infections based on Day +30 vitamin A level above or below the median. Biology of Blood and Marrow Transplantation 2017 23, DOI: (10.1016/j.bbmt.2017.01.048) Copyright © 2016 Terms and Conditions

Figure 2 Cumulative incidence of GI GVHD based on Day +7 I-FABP levels above or below the median. Biology of Blood and Marrow Transplantation 2017 23, DOI: (10.1016/j.bbmt.2017.01.048) Copyright © 2016 Terms and Conditions

Figure 3 I-FABP levels at Day +7 are lower in patients who received a myeloablative (MAB) preparative regimen with a median of 444 pg/mL (range 258.9-634.2 pg/mL) versus a reduced intensity (RIC) preparative regimen with a median of 696.3 pg/mL (range 318.1-1020 pg/mL). Biology of Blood and Marrow Transplantation 2017 23, DOI: (10.1016/j.bbmt.2017.01.048) Copyright © 2016 Terms and Conditions