Impact of statin therapy on patients with coronary heart disease and aortic aneurysm or dissection Junichi Tazaki, MD, Takeshi Morimoto, MD, PhD, Ryuzo.

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Presentation transcript:

Impact of statin therapy on patients with coronary heart disease and aortic aneurysm or dissection Junichi Tazaki, MD, Takeshi Morimoto, MD, PhD, Ryuzo Sakata, MD, Hitoshi Okabayashi, MD, Fumio Yamazaki, MD, Noboru Nishiwaki, MD, Kazuaki Mitsudo, MD, Takeshi Kimura, MD Journal of Vascular Surgery Volume 60, Issue 3, Pages 604-612.e2 (September 2014) DOI: 10.1016/j.jvs.2014.03.280 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 1 Study flow chart. CABG, Coronary artery bypass grafting; PCI, percutaneous coronary intervention. Journal of Vascular Surgery 2014 60, 604-612.e2DOI: (10.1016/j.jvs.2014.03.280) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 2 Kaplan-Meier event curves: patients with vs without aortic aneurysm or dissection (AD) for a composite of all-cause death, myocardial infarction (MI), and stroke. The estimated event-free survival ± standard error was 90% ± 1.1% in the AD group vs 93% ± 0.2% in the no AD group at 1 year, 82% ± 1.5% vs 90% ± 0.3% at 2 years, 78% ± 1.6% vs 86% ± 0.3% at 3 years, 72% ± 1.8% vs 82% ± 0.3% at 4 years, and 65% ± 1.9% vs 78% ± 0.4% at 5 years (P < .0001), respectively. Journal of Vascular Surgery 2014 60, 604-612.e2DOI: (10.1016/j.jvs.2014.03.280) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 3 Kaplan-Meier event curves: Patients with vs without repair of aortic aneurysm or dissection (AD) aortic disease for a composite of all-cause death, myocardial infarction (MI), and stroke. The estimated event-free survival ± standard error was 93% ± 1.8% in the group with repair vs 88% ± 1.5% in the group without repair at 1 year, 84% ± 2.5% vs 81% ± 1.8% at 2 years, 79% ± 2.8% vs 77% ± 1.9% at 3 years, 74% ± 3.0% vs 71% ± 2.1% at 4 years, and 67% ± 3.3% vs 64% ± 2.3% at 5 years (P = .72), respectively. Journal of Vascular Surgery 2014 60, 604-612.e2DOI: (10.1016/j.jvs.2014.03.280) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 4 Kaplan-Meier event curves: statins vs no statins in patients with aortic aneurysm and dissection (AD) and without AD for a composite of all-cause death, myocardial infarction (MI), and stroke. The estimated event-free survival ± standard error was 87% ± 1.7% in the AD(+) Statin(−) group vs 95% ± 1.3% in the AD(+) Statin(+) group vs 92% ± 0.3% in the AD(−) Statin(−) group vs 95% ± 0.3% in the AD(−) Statin(+) at 1 year, 79% ± 2.0% vs 87% ± 2.0% vs 88% ± 0.4% vs 92% ± 0.3% at 2 years, 73% ± 2.2% vs 85% ± 2.2% vs 83% ± 0.5% vs 89% ± 0.4% at 3 years, 68% ± 2.3% vs 78% ± 2.5% vs 79% ± 0.5% vs 86% ± 0.4% at 4 years, and 61% ± 2.5% vs 71% ± 2.9% vs 74% ± 0.5% vs 83% ± 0.5% at 5 years, respectively. Journal of Vascular Surgery 2014 60, 604-612.e2DOI: (10.1016/j.jvs.2014.03.280) Copyright © 2014 Society for Vascular Surgery Terms and Conditions