Osteoarthritis and Cartilage

Slides:



Advertisements
Similar presentations
Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.
Advertisements

Micro-CT bone structure evaluation in the Pond-Nuki dog model
Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative  M. Hakky, M. Jarraya,
P.B. Chan, W. Yang, C. Wen, C. Yan, K. Chiu 
P.-S. Hsu, H.-H. Lin, C.-R. Li, W.-S. Chung 
Osteoarthritis and Cartilage
S. Gavard  Osteoarthritis and Cartilage 
Gene expression profiling for confirmation of effects of DNA polymeric molecules on in vitro arthritis model  H.-J. Kim, A. Baek, M. Kim, S.-R. Cho  Osteoarthritis.
M. Baharuddin, S.-H. Salleh, M. Lee, A. Mohd Noor 
Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis  M. Chung, N. Zhao, J.B. Wong, C. Wang  Osteoarthritis.
Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative  M.A. Bowes, C.B. Wolstenholme,
K. I. Barton, B. J. Heard, N. M. Solbak, M. Chung, Y. Achari, N. G
Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain  C. Ratzlaff, R. Russell, J. Duryea  Osteoarthritis.
Role of endothelin-1 in endochondral ossification and osteoarthritis
Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis  S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim 
G. Venne, S. Pang, Y. Tse, R. Ellis  Osteoarthritis and Cartilage 
Change in bone area does not correlate with cartilage loss over 12 months in individuals with knee OA: Data from the osteoarthritis initiative  M.A. Bowes,
Spatial variation of cartilage stiffness at micro and macro scale
Osteoarthritis and Cartilage
Osteoarthritis and Cartilage
Preliminary study: non destructive evaluation of early cartilage morphological changes in a rabbit model by equilibrium partitioning of an ionic contrast.
Osteoarthritis and Cartilage
Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations 
Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain  J.R. Connor,
The S100A9 inhibitor paquinimod (ABR ) reduces synovial activation, osteophyte formation and cartilage damage in experimental osteoarthritis  R.F.
J. Avouac, M.D., L. Gossec, M.D., M. Dougados, M.D. 
Development of Asian hip stem 5 – Primary stability classification using time domain features and support vector machine  M. Baharuddin, S.-H. Salleh,
Role of periostin and discoidin domain receptor-1 (DDR1) in the regulation of cartilage degeneration and expression of MMP-13  M. Attur, Q. Yang, T. Kirsch,
Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes
Osteoarthritis and Cartilage
N. Bodick, J. Lufkin, C. Willwerth, A. Kumar, J. Bolognese, C
Osteoarthritis and Cartilage
Water-soluble C60-(OH)24 fullerene hydroxide as a therapeutic agent against the degeneration of articular cartilage in osteoarthritis  N. Yui, H. Yoshioka,
K.S. Vanderman, R. Loeser, S. Chubinskaya, C.M. Ferguson 
N. Segal, E. Frick, M. Nevitt, J. Torner, D. Felson, A. Guermazi, D
Osteoarthritis and Cartilage
Osteoarthritis and Cartilage
A cartilage-targeted insulin-like growth factor-1 is retained in cartilage and promotes extracellular matrix maintenance in rat medial meniscus tear model 
Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI  M.A. Bowes, B.T. Drew, A.C. Redmond, B.
Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells  M. Au, M. Zhu, W.-J.
Immediate effects of a varus unloader brace on lateral knee osteoarthritis after anterior cruciate ligament reconstruction during stair ascent and stair.
N. Khalaj, N.A. Osman, W. Wan Abas, A. Mokhtar 
A single center, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy and safety of intra-articular onabotulinumtoxina as.
Z. Huang, T. Stabler, F. Pei, V. Kraus  Osteoarthritis and Cartilage 
Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study  Z. Zhu, L.L. Laslett, W. Han,
Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography  N.J. Willett, T. Thote, M. Hart,
Osteoarthritis and Cartilage
A.B. Lovati, A. Pozzi, M. Bongio, C. Recordati, G. Berzero, M. Moretti 
P. Rahnamay Moshtagh, N. M. Korthagen, S. G. Plomp, B. Pouran, A
Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative  E. Halilaj, T.J. Hastie, G.E. Gold,
Osteoarthritis and Cartilage
Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study  C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu 
Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study  L. Busija, R. Buchbinder, R.H. Osborne  Osteoarthritis.
Osteoarthritis year 2012 in review: biology
Dancing transcription factors: What makes SOX9 move?
Comparative evaluations of matrix alterations in the ovine menisci following joint injury or reconstructive surgery  K. Barton, M. Wiebe, Y. Achari, C.B.
Examining the relationship between degenerative anterior cruciate ligament lesions and patellofemoral cartilage integrity with quantitative magnetic resonance.
The elastic modulus of articular cartilage at nano-scale and micro-scale measured using indentation type atomic force microscopy  P. Rahnamay Moshtagh,
J.H. Ylärinne, C. Qu, M.J. Lammi  Osteoarthritis and Cartilage 
Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed  A.G. Fischer, E.M. Debbi, A. Wolf 
Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis  J.D. Hood, V.
In situ evaluation of chondrofix® osteochondral allograft 25 months following implantation: A case report  K.L. Reynolds, S.K. Bishai  Osteoarthritis.
Osteoarthritis and Cartilage
Does the meniscal symptom index include the symptoms most important for middle- aged patients with degenerative meniscal tears eligible for surgery?  K.B.
3D feature severity mapping of the hip with computed tomography reveals patterns of radiological osteoarthritis  T.D. Turmezei, D.J. Lomas, M.A. Hopper,
Fully automated segmentation of cartilage from magnetic resonance images using improved 3D shape context and active shape model  T. Ye, X. Cui, H. Kim 
A. Carlson, B. Bothner, R. June  Osteoarthritis and Cartilage 
General Information Osteoarthritis and Cartilage
Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years  B. Antony, S. Zheng, J. Burgess,
Tibial cartilage creep during weight bearing: in vivo 3D CT assessment
Presentation transcript:

Osteoarthritis and Cartilage Contrast-based micro-CT analysis of MMP inhibitor efficacy in a rat osteoarthritis model  T. Thote, N.J. Willett, M.A. Hart, A.S. Lin, S. Moran, R.E. Guldberg, R.V. Kamath  Osteoarthritis and Cartilage  Volume 21, (April 2013) DOI: 10.1016/j.joca.2013.02.468 Copyright © 2013 Terms and Conditions

Figure 1 Delineation of osteophyte (OP) and representative images from experimental groups. Osteoarthritis and Cartilage 2013 21, DOI: (10.1016/j.joca.2013.02.468) Copyright © 2013 Terms and Conditions

Figure 2 Quantification of osteophyte parameters. Osteoarthritis and Cartilage 2013 21, DOI: (10.1016/j.joca.2013.02.468) Copyright © 2013 Terms and Conditions

Figure 3 Evaluation of medial 1/3 cartilage volume and lesion volume. Osteoarthritis and Cartilage 2013 21, DOI: (10.1016/j.joca.2013.02.468) Copyright © 2013 Terms and Conditions