Franco Locatelli, Damiano Rondelli, G.Roberto Burgio

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Presentation transcript:

Tolerance and hematopoietic stem cell transplantation 50 years after Burnet's theory Franco Locatelli, Damiano Rondelli, G.Roberto Burgio Experimental Hematology Volume 28, Issue 5, Pages 479-489 (May 2000) DOI: 10.1016/S0301-472X(00)00153-3

Figure 1 Possible biologic approaches for inducing alloantigen-specific tolerance. DC-2 indicates type 2 dendritic cells Experimental Hematology 2000 28, 479-489DOI: (10.1016/S0301-472X(00)00153-3)

Figure 2 Induction of antigen-specific unresponsiveness through blockade of costimulatory molecules (i.e., blockade of signal 2). APC = antigen presenting cell; TCR = T-cell receptor; LFA-1 = leukocyte function antigen-1; ICAM-1 = intercellular adhesion molecule-1 Experimental Hematology 2000 28, 479-489DOI: (10.1016/S0301-472X(00)00153-3)