Cor de Wit, Steffen-Sebastian Bolz, Jörg Kaas, Ulrich Pohl

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Myogenic effects enhance norepinephrine constriction: Inhibition by nitric oxide and felodipine Cor de Wit, Steffen-Sebastian Bolz, Jörg Kaas, Ulrich Pohl Kidney International Volume 54, Pages S122-S126 (September 1998) DOI: 10.1046/j.1523-1755.1998.06723.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Effect of intravenous norepinephrine (NE) infusion on cremaster inflow pressure (A) and diameter (B) of small (diameter < 65 μm, N = 7) or large arterioles (diameter 65 to 115 μm, N = 6). Local treatment of the cremaster tissue with adrenoceptor blockers (LAB) did not affect pressure increases and the subsequent vasoconstriction of small arterioles. Prevention of the increase of pressure by inflation of the aortic occluder (OCC) abolished the constriction despite continuous presence of NE. Symbols are: (□) control; (▧) LAB; (▪) OCC. *P < 0.05 versus resting diameter. Kidney International 1998 54, S122-S126DOI: (10.1046/j.1523-1755.1998.06723.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Effect of inflow pressure (A) on diameters (B) of small or large arterioles in untreated vessels (N = 37; □, control) following nitric oxide (NO) synthase inhibition by Nω-nitro-L-arginine (LNNA, N = 37; ▧) or treatment with felodipine (N = 21; ▪). *P < 0.05 versus resting diameter at 60mm Hg. Kidney International 1998 54, S122-S126DOI: (10.1046/j.1523-1755.1998.06723.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Effect of transmural pressure increase on vascular diameters (B) and smooth muscle Ca2+(R = ratio F340/F380, A) of small artery segments (isolated from hamster gracilis muscle) before (□, control) and after treatment with felodipine (N = 7; ▧). Mean values were obtained 10, 60, and 180 seconds after pressure increase from 45 to 110mm Hg. Control values at 45mm Hg were diameter, 158 ± 15 versus 174 ± 13 μm, and R, 1.08 ± 0.2 versus 0.84 ± 0.2 (untreated versus felodipine). Kidney International 1998 54, S122-S126DOI: (10.1046/j.1523-1755.1998.06723.x) Copyright © 1998 International Society of Nephrology Terms and Conditions