Long-term fetal outcome after fetal cardiac bypass: Fetal survival to full term and organ abnormalities V.Mohan Reddy, MD, John R. Liddicoat, MD, Judith.

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Presentation transcript:

Long-term fetal outcome after fetal cardiac bypass: Fetal survival to full term and organ abnormalities V.Mohan Reddy, MD, John R. Liddicoat, MD, Judith R. Klein, MD, Richard K. Wampler, MD, Frank L. Hanley, MD The Journal of Thoracic and Cardiovascular Surgery Volume 111, Issue 3, Pages 536-544 (March 1996) DOI: 10.1016/S0022-5223(96)70305-7 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Fetal cardiac bypass circuit: A, Arterial cannula; D, drive cable; F, flow probe; H, Hemopump device14; M, electromagnet; T, Y connector; V, venous cannula. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 536-544DOI: (10.1016/S0022-5223(96)70305-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Weight of the study lambs (fetuses, n = 9; newborn, n = 8; 7 days old, n = 7) and normal lambs (n = 5). The growth of the lambs delivered after fetal cardiac bypass was similar to that of normal lambs. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 536-544DOI: (10.1016/S0022-5223(96)70305-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Microscopic appearance (×100) of the left ventricular free wall showing normal myocardial cells and fiber architecture. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 536-544DOI: (10.1016/S0022-5223(96)70305-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Microscopic appearance (×100) of a section from the cerebral cortex of a fetus that died after fetal cardiac bypass. Note the cortical neuronal loss, which is suggestive of hypoxia or low flow to the brain. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 536-544DOI: (10.1016/S0022-5223(96)70305-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Microscopic appearance (×100) of cerebral cortex of a lamb that was subjected to fetal cardiac bypass as a fetus. No abnormalities were noted. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 536-544DOI: (10.1016/S0022-5223(96)70305-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 6 Microscopic appearance (×100) of a cerebellar section of a lamb (long-term survivor after fetal cardiac bypass). Note that the Purkinje neurons look normal. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 536-544DOI: (10.1016/S0022-5223(96)70305-7) Copyright © 1996 Mosby, Inc. Terms and Conditions