Local photodynamic action of methylene blue favorably modulates the postinterventional vascular wound healing response Joerg Heckenkamp, MD, Farzin Adili,

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Presentation transcript:

Local photodynamic action of methylene blue favorably modulates the postinterventional vascular wound healing response Joerg Heckenkamp, MD, Farzin Adili, MD, Jiro Kishimoto, PhD, Manuel Koch, PhD, Glenn M. LaMuraglia, MD Journal of Vascular Surgery Volume 31, Issue 6, Pages 1168-1177 (June 2000) DOI: 10.1067/mva.2000.106491 Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Fluorescent micrographs of rat common carotid arteries directly after balloon-injury, untreated (A) or after the local delivery of 250 μg/mL methylene blue (B). The internal elastic lamina (arrow ) is noted. Excitation of unstained frozen sections was performed at 476 nm with a fluorescence capture between 620 and 630 nm. Note the high-fluorescence signal throughout the vessel wall after local delivery of the photosensitizer. The scale bar equals 50 μm. Journal of Vascular Surgery 2000 31, 1168-1177DOI: (10.1067/mva.2000.106491) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Light micrographs of rat common carotid arteries stained with hematoxylin and eosin 2 weeks after balloon-injury, untreated (A) or photodynamic therapy-treated (B). The internal elastic lamina (arrow ) is noted. In photodynamic therapy-treated arteries, no intimal hyperplasia was seen; the media was cell free. The scale bar equals 50 m. Journal of Vascular Surgery 2000 31, 1168-1177DOI: (10.1067/mva.2000.106491) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Localization and quantitation of versican messenger RNA in the rat common carotid arteries stained 2 weeks after balloon-injury, untreated (A) or photodynamic therapy-treated (B). The internal elastic lamina (arrow ) is noted. The scale bar equals 50 μm. Journal of Vascular Surgery 2000 31, 1168-1177DOI: (10.1067/mva.2000.106491) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Localization and quantitation of procollagen type I messenger RNA in the rat common carotid arteries stained 2 weeks after balloon-injury, untreated (A) or photodynamic therapy-treated (B). The internal elastic lamina (arrow ) is noted. The scale bar equals 50 μm. Journal of Vascular Surgery 2000 31, 1168-1177DOI: (10.1067/mva.2000.106491) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions