Rewiring Bacteria, Two Components at a Time

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Rewiring Bacteria, Two Components at a Time Michael A. Kohanski, James J. Collins Cell Volume 133, Issue 6, Pages 947-948 (June 2008) DOI: 10.1016/j.cell.2008.05.035 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Rewiring a Bacterial Two-Component System (Top) Shown is the native EnvZ-OmpR two-component signal transduction system (red) from the bacteria Escherichia coli for sensing and responding to osmolarity changes. (Bottom) A theoretical EnvZ sensor (red) rewired for chemotaxis pathway (CheA-CheY; blue) specificity, which still senses osmolarity changes but responds by initiating expression of chemotaxis genes. Cell 2008 133, 947-948DOI: (10.1016/j.cell.2008.05.035) Copyright © 2008 Elsevier Inc. Terms and Conditions