Nitecapone as an additive to crystalloid cardioplegia in patients who had coronary artery bypass grafting Antti E Vento, MD, Juha Aittomäki, MD, Kalervo.

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Copyright © 2008 Thomson Delmar Learning CHAPTER 15 Hemodynamic Measurements.

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Presentation transcript:

Nitecapone as an additive to crystalloid cardioplegia in patients who had coronary artery bypass grafting Antti E Vento, MD, Juha Aittomäki, MD, Kalervo A Verkkala, MD, PhD, Lasse J Heikkilä, MD, PhD, Jarmo A Salo, MD, PhD, Jorma Sipponen, MD, PhD, O.Juhani Rämö, MD, PhD The Annals of Thoracic Surgery Volume 68, Issue 2, Pages 413-420 (August 1999) DOI: 10.1016/S0003-4975(99)00514-7

Fig 1 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Heart rate (HR) was increased in both groups and was lower in the nitecapone (NC) group than in the control (C) group (p = 0.06). (ind =induction of anesthesia). The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 2 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Mean arterial pressure (MAP) was over 60 mm Hg in both groups (p = 0.66). Abbreviations as in Figure 1. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 3 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Cardiac output (CO) reflected better myocardial recovery at 6 and 24 hours after CPB (p = 0.75). Abbreviations as in Figure 1. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 4 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Cardiac Index (CI) reflected better myocardial recovery at 6 and 24 hours after CPB (p = 0.67). Abbreviations as in Figure 1. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 5 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Stroke volume (SV) reflected better myocardial recovery at 6 and 24 hours after CPB (p = 0.37). Abbreviations as in Figure 1. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 6 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Central venous pressure (CVP) was similarly increased in both groups after CPB (p = 0.82). Abbreviations as in Figure 1. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 7 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Pulmonary artery diastolic pressure (PAPD) showed no major differences between the groups (p = 0.05). Abbreviations as in Figure 1. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 8 Hemodynamics in induction, before cross-clamping, after cross-clamping, when the sternum was closed, and 2, 3, 6, and 24 hours after cardiopulmonary bypass (CPB). Pulmonary capillary wedge pressure (PCWP) showed minor differences between the groups (p = 0.26). Abbreviations as in Figure 1. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 9 Gradient between coronary sinus and aorta with regard to low-density lipoprotein–peroxyl radical trapping antioxidant potential in relation to cholesterol concentration. (LDL TRAP CHOL) (μmol/L) showed that nitecapone (NC)-treated patients had better antioxidant potential than the control (C) group at 5 minutes after declamping (p < 0.05). 1 AD, 2 AD, and 3 AD = 1, 5, and 10 minutes after declamping, respectively. The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)

Fig 10 Myeloperoxidase activity of the myocardial biopsy (mU/mg of protein) was higher in the control (C) group but lower in the nitecapone (NC) group (p = 0.13). The Annals of Thoracic Surgery 1999 68, 413-420DOI: (10.1016/S0003-4975(99)00514-7)