Histological evidence of alveolar epithelial cells undergoing epithelial-mesenchymal transition in response to transforming growth factor-β1. a–c) α-smooth.

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Presentation transcript:

Histological evidence of alveolar epithelial cells undergoing epithelial-mesenchymal transition in response to transforming growth factor-β1. a–c) α-smooth muscle actin (α-SMA) and pro surfactant protein (SP)-B or d–f) α-SMA and thyroid transcription factor... Histological evidence of alveolar epithelial cells undergoing epithelial-mesenchymal transition in response to transforming growth factor-β1. a–c) α-smooth muscle actin (α-SMA) and pro surfactant protein (SP)-B or d–f) α-SMA and thyroid transcription factor-1. a, d) Low-power images reveal severe destruction of normal lung architecture due to fibrosis. High-power images (two representative fields from within the low-power field shown) reveal abundant epithelial cells adjacent to b, c) fibroblastic foci co-expressing SP-B and α-SMA or e, f) thyroid transcription factor-1 and α-SMA. Reproduced from [13] with permission from the publisher. P. W. Noble Eur Respir Rev 2008;17:123-129 ©2008 by European Respiratory Society