Immunologic cross-reactivity between respiratory chemical sensitizers: Reactive dyes and cyanuric chloride Meinir Jones, PhDa, Cynthia Graham, PhDb,

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Presentation transcript:

Immunologic cross-reactivity between respiratory chemical sensitizers: Reactive dyes and cyanuric chloride Meinir Jones, PhDa, Cynthia Graham, PhDb, Anthony Newman Taylor, FRCP, FFOMa, Katherine Sarlo, PhDc, Viviene Hoyle, PhDd, Meryl H. Karol, PhDb Journal of Allergy and Clinical Immunology Volume 102, Issue 5, Pages 835-840 (November 1998) DOI: 10.1016/S0091-6749(98)70025-9 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Structures of CyCl, PrOr, and Rem B. Journal of Allergy and Clinical Immunology 1998 102, 835-840DOI: (10.1016/S0091-6749(98)70025-9) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 RAST and RAST inhibition of serum C547. A, Serum from this PrOr-exposed worker demonstrated 10.6% RAST binding to PrOr-HSA–coated disks that was inhibited by PrOr-HSA (1.6% binding), but not by CyCl-HSA (10.0% binding). B, Serum demonstrated 1.8% RAST binding to CyCl-HSA disks. Binding was inhibited equally by PrOr-HSA (0.7% binding) and by CyCl-HSA (0.9% binding). Journal of Allergy and Clinical Immunology 1998 102, 835-840DOI: (10.1016/S0091-6749(98)70025-9) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Prediction of allergenic features of PrOr by using Structure Activity Relationship model. Journal of Allergy and Clinical Immunology 1998 102, 835-840DOI: (10.1016/S0091-6749(98)70025-9) Copyright © 1998 Mosby, Inc. Terms and Conditions