Volume 16, Issue 5, Pages (November 2012)

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Volume 16, Issue 5, Pages 658-664 (November 2012) Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance Jun Yoshino, Caterina Conte, Luigi Fontana, Bettina Mittendorfer, Shin-ichiro Imai, Kenneth B. Schechtman, Charles Gu, Iris Kunz, Filippo Rossi Fanelli, Bruce W. Patterson, Samuel Klein Cell Metabolism Volume 16, Issue 5, Pages 658-664 (November 2012) DOI: 10.1016/j.cmet.2012.09.015 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Liver, Adipose Tissue, and Skeletal Muscle Insulin Sensitivity Insulin-mediated suppression of glucose rate of appearance (Ra) (A), insulin-mediated suppression of palmitate Ra (B), insulin-mediated increase in glucose rate of disappearance (Rd) (C), and absolute glucose Rd values (D) before (white bars) and after (black bars) placebo (n = 14) or resveratrol (n = 15) supplementation. Values are means ± SE. See also Table S2. Cell Metabolism 2012 16, 658-664DOI: (10.1016/j.cmet.2012.09.015) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Assessment of Putative Resveratrol Molecular Targets Relative gene expressions of SIRTt1, nicotinamide phosphoribosyltransferase (NAMPT), PPARGC1A, and UCP3 (means ± SE) determined by quantitative PCR in skeletal muscle (upper panel) and adipose tissue (lower panel) before (white bars) and after (black bars) placebo or resveratrol supplementation (n = 8–12 per group) (A). Microarray analyses were performed with skeletal muscle and adipose tissue biopsy samples. GSEA was used to identify potential biological pathways affected by resveratrol. Representative resveratrol target pathways related to mitochondrial function, inflammation, and AMPK are shown (B). The levels of phosphorylated AMPKα (Thr172) and total AMPKα in skeletal muscle from four subjects before (white bars) and after (black bars) resveratrol supplementation were determined by using western blotting (C). Values are means ± SE. See also Figure S1. Cell Metabolism 2012 16, 658-664DOI: (10.1016/j.cmet.2012.09.015) Copyright © 2012 Elsevier Inc. Terms and Conditions