Osteoarthritis and Cartilage

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Osteoarthritis and Cartilage Chondrocyte death and mitochondrial dysfunction are mediated by cartilage friction and shear strain E.D. Bonnevie, M.L. Delco, N. Jasty, L. Bartell, L.A. Fortier, I. Cohen, L.J. Bonassar Osteoarthritis and Cartilage Volume 24, (April 2016) DOI: 10.1016/j.joca.2016.01.107 Copyright © 2016 Terms and Conditions

Figure 1 (A) Friction coefficient vs sliding speed (n = 4). (B) Local shear strains were tracked on a confocal microscope. (C) Local shear strains were high in PBS lubricated tissue compared to control. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.107) Copyright © 2016 Terms and Conditions

Figure 2 (A-C) Live/dead staining. (D) Percent cell death vs tissue depth. (E-G) MT (green) and active MT (red) staining. (D) Percent MT dysfunction vs tissue depth (n = 4). Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.107) Copyright © 2016 Terms and Conditions